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Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature.

Dahiya S, Ooi WB, Mallidi J, Sivalingam S, Steingart R - Rare Tumors (2012)

Bottom Line: Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers.PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues.A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

View Article: PubMed Central - PubMed

Affiliation: Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.

ABSTRACT
Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers. PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues. We present a case of PTL with huge left atrial mass, an extremely unusual site of involvement. Early disease usually carries a good prognosis, whereas advanced stage carries an extremely poor prognosis. Herein, we report the complete remission to date in a patient with advanced stage PTL with huge left atrial mass, treated with systemic rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone and intrathecal methotrexate. A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

No MeSH data available.


Related in: MedlinePlus

Positron emission tomography-computed tomography showing hypermetabolic activity in left atrium at presentation.
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Related In: Results  -  Collection


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Figure 2: Positron emission tomography-computed tomography showing hypermetabolic activity in left atrium at presentation.

Mentions: For staging purposes, a bone marrow biopsy and lumber puncture was performed which showed no lymphomatous involvement. Positron emission tomography-CT (PET-CT) showed hypermetabolic activity in suprapubic area, left atrium and left testes (Figure 2). A diagnosis of stage IV testicular lymphoma was made, given the presence of testicular mass, locoregional nodal involvement (suprapubic mass) and distant extranodal site involvement (intracardiac mass). His international prognostic index score was calculated to 4 (age greater than 60, high LDH, more than 1 extranodal site involvement, Ann Arbor stage IV and an ECOG performance status of 1).


Primary testicular lymphoma with cardiac involvement in an immunocompetent patient: case report and a concise review of literature.

Dahiya S, Ooi WB, Mallidi J, Sivalingam S, Steingart R - Rare Tumors (2012)

Positron emission tomography-computed tomography showing hypermetabolic activity in left atrium at presentation.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475950&req=5

Figure 2: Positron emission tomography-computed tomography showing hypermetabolic activity in left atrium at presentation.
Mentions: For staging purposes, a bone marrow biopsy and lumber puncture was performed which showed no lymphomatous involvement. Positron emission tomography-CT (PET-CT) showed hypermetabolic activity in suprapubic area, left atrium and left testes (Figure 2). A diagnosis of stage IV testicular lymphoma was made, given the presence of testicular mass, locoregional nodal involvement (suprapubic mass) and distant extranodal site involvement (intracardiac mass). His international prognostic index score was calculated to 4 (age greater than 60, high LDH, more than 1 extranodal site involvement, Ann Arbor stage IV and an ECOG performance status of 1).

Bottom Line: Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers.PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues.A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

View Article: PubMed Central - PubMed

Affiliation: Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.

ABSTRACT
Primary testicular lymphoma (PTL) is a rare testicular tumor representing less than 9% of all testicular cancers. PTL usually tends to spread to or relapse at nodal structures or extra-nodal sites such as contralateral testes, central nervous system, skin, lung, pleura, waldeyer's ring and soft tissues. We present a case of PTL with huge left atrial mass, an extremely unusual site of involvement. Early disease usually carries a good prognosis, whereas advanced stage carries an extremely poor prognosis. Herein, we report the complete remission to date in a patient with advanced stage PTL with huge left atrial mass, treated with systemic rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone and intrathecal methotrexate. A brief review of literature focusing on various aspects of management of primary testicular lymphoma and lymphomatous involvement of heart is also discussed.

No MeSH data available.


Related in: MedlinePlus