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Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemistry: A) myeloperoxidase strongly positive in tumor cells (400×); B) LCA (CD45) was negative in tumor cells, infiltrating normal lymphocytes are positive (400×); C) placental alkaline phosphatase is negative in tumor cells (400×); D) vimentin is negative in tumor cells (400×).
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Figure 3: Immunohistochemistry: A) myeloperoxidase strongly positive in tumor cells (400×); B) LCA (CD45) was negative in tumor cells, infiltrating normal lymphocytes are positive (400×); C) placental alkaline phosphatase is negative in tumor cells (400×); D) vimentin is negative in tumor cells (400×).

Mentions: Immunohistochemistry for myeloperoxidase, LCA (CD45), CD 34, and placental alkaline phosphatase was done. It was strongly positive for myeloperoxidase. Rest three were negative (Figures 3A–D). A diagnosis of granulocytic sarcoma was confirmed.


Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

Immunohistochemistry: A) myeloperoxidase strongly positive in tumor cells (400×); B) LCA (CD45) was negative in tumor cells, infiltrating normal lymphocytes are positive (400×); C) placental alkaline phosphatase is negative in tumor cells (400×); D) vimentin is negative in tumor cells (400×).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475943&req=5

Figure 3: Immunohistochemistry: A) myeloperoxidase strongly positive in tumor cells (400×); B) LCA (CD45) was negative in tumor cells, infiltrating normal lymphocytes are positive (400×); C) placental alkaline phosphatase is negative in tumor cells (400×); D) vimentin is negative in tumor cells (400×).
Mentions: Immunohistochemistry for myeloperoxidase, LCA (CD45), CD 34, and placental alkaline phosphatase was done. It was strongly positive for myeloperoxidase. Rest three were negative (Figures 3A–D). A diagnosis of granulocytic sarcoma was confirmed.

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus