Limits...
Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus

A) Large proliferating blood vessel surrounded by monomorphic population of small round cells (Hematoxylin & Eosin 100×); B) hyperchromatic small round cells had high N:C ratio, coarse chromatin and scant to moderate amount of basophilic cytoplasm (Hematoxylin & Eosin 100×); C) Fine needle aspiration (FNA) left breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); D) FNA right breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); E) FNA leg swelling: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); F) peripheral blood smear: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3475943&req=5

Figure 2: A) Large proliferating blood vessel surrounded by monomorphic population of small round cells (Hematoxylin & Eosin 100×); B) hyperchromatic small round cells had high N:C ratio, coarse chromatin and scant to moderate amount of basophilic cytoplasm (Hematoxylin & Eosin 100×); C) Fine needle aspiration (FNA) left breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); D) FNA right breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); E) FNA leg swelling: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); F) peripheral blood smear: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×).

Mentions: Sections processed showed monomorphic population of small round cells diffusely infiltrating the ovarian stroma. These cells were discohesive, lying in sheets and separated by fibrous strands of variable thickness. Cells were hyperchromatic, had high nuclear cytoplasmic ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm. One-two mitotic figures per high power field were noted. One section showed large corpus luteum of ovary with central area of hemorrhage (Figures 1C–E and 2A,B).


Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

A) Large proliferating blood vessel surrounded by monomorphic population of small round cells (Hematoxylin & Eosin 100×); B) hyperchromatic small round cells had high N:C ratio, coarse chromatin and scant to moderate amount of basophilic cytoplasm (Hematoxylin & Eosin 100×); C) Fine needle aspiration (FNA) left breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); D) FNA right breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); E) FNA leg swelling: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); F) peripheral blood smear: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475943&req=5

Figure 2: A) Large proliferating blood vessel surrounded by monomorphic population of small round cells (Hematoxylin & Eosin 100×); B) hyperchromatic small round cells had high N:C ratio, coarse chromatin and scant to moderate amount of basophilic cytoplasm (Hematoxylin & Eosin 100×); C) Fine needle aspiration (FNA) left breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); D) FNA right breast: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); E) FNA leg swelling: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×); F) peripheral blood smear: large round to oval cells with high nuclear cytoplasmic ratio and 2 to 4 nucleoli (Giemsa 1000×).
Mentions: Sections processed showed monomorphic population of small round cells diffusely infiltrating the ovarian stroma. These cells were discohesive, lying in sheets and separated by fibrous strands of variable thickness. Cells were hyperchromatic, had high nuclear cytoplasmic ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm. One-two mitotic figures per high power field were noted. One section showed large corpus luteum of ovary with central area of hemorrhage (Figures 1C–E and 2A,B).

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus