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Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus

A) Gross: lobulated solid mass of ovary; B) cut surface of masses was tan grey with raised lobulated areas; C) monomorphic population of small round cells diffusely infiltrating the ovarian stroma with large corpus luteum of ovary, (arrow; Hematoxylin & Eosin 100×); D) monomorphic population of small round cells infiltrating the capsular (Hematoxylin & Eosin 100×); E) monomorphic population of small round cells diffusely infiltrating the ovarian stroma adjescent to leuteal cells (arrow, Hematoxylin & Eosin 100×); F) proliferating blood vessels and diffuse infiltration of hyperchromatic small round cells with high N:C ratio (Hematoxylin & Eosin 400×).
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Figure 1: A) Gross: lobulated solid mass of ovary; B) cut surface of masses was tan grey with raised lobulated areas; C) monomorphic population of small round cells diffusely infiltrating the ovarian stroma with large corpus luteum of ovary, (arrow; Hematoxylin & Eosin 100×); D) monomorphic population of small round cells infiltrating the capsular (Hematoxylin & Eosin 100×); E) monomorphic population of small round cells diffusely infiltrating the ovarian stroma adjescent to leuteal cells (arrow, Hematoxylin & Eosin 100×); F) proliferating blood vessels and diffuse infiltration of hyperchromatic small round cells with high N:C ratio (Hematoxylin & Eosin 400×).

Mentions: Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Outer surface was encapsulated and cut surface of both the masses was tan grey with multiple small hemorrhagic and brownish areas (Figure 1A, B). Several pieces from different areas including center and outer surface were processed from both masses.


Aleukemic granulocytic sarcoma presenting at multiple sites: ovary, breast and soft tissue.

Nigam JS, Misra V, Kumar V, Varma K - Rare Tumors (2012)

A) Gross: lobulated solid mass of ovary; B) cut surface of masses was tan grey with raised lobulated areas; C) monomorphic population of small round cells diffusely infiltrating the ovarian stroma with large corpus luteum of ovary, (arrow; Hematoxylin & Eosin 100×); D) monomorphic population of small round cells infiltrating the capsular (Hematoxylin & Eosin 100×); E) monomorphic population of small round cells diffusely infiltrating the ovarian stroma adjescent to leuteal cells (arrow, Hematoxylin & Eosin 100×); F) proliferating blood vessels and diffuse infiltration of hyperchromatic small round cells with high N:C ratio (Hematoxylin & Eosin 400×).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475943&req=5

Figure 1: A) Gross: lobulated solid mass of ovary; B) cut surface of masses was tan grey with raised lobulated areas; C) monomorphic population of small round cells diffusely infiltrating the ovarian stroma with large corpus luteum of ovary, (arrow; Hematoxylin & Eosin 100×); D) monomorphic population of small round cells infiltrating the capsular (Hematoxylin & Eosin 100×); E) monomorphic population of small round cells diffusely infiltrating the ovarian stroma adjescent to leuteal cells (arrow, Hematoxylin & Eosin 100×); F) proliferating blood vessels and diffuse infiltration of hyperchromatic small round cells with high N:C ratio (Hematoxylin & Eosin 400×).
Mentions: Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Outer surface was encapsulated and cut surface of both the masses was tan grey with multiple small hemorrhagic and brownish areas (Figure 1A, B). Several pieces from different areas including center and outer surface were processed from both masses.

Bottom Line: Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma.Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells.Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India.

ABSTRACT
An 18 year old female presented with the history of pain in abdomen, breast engorgement, swelling over both legs and breathlessness for three month. On clinical examination diagnosis of fibroadenoma breast was made. Ultrasonography of abdomen showed bilateral ovarian mass. Bilateral salpingo-ophrectomy was done and specimen was sent for histological examination. Two lobulated solid masses of tissues the larger one measuring 13×8×5 cm and smaller one measuring 10×7×5 cm in size received. Microscopic examination showed monomorphic population of discohesive, hyperchromatic small round cells had high N:C ratio, coarse chromatin, conspicuous nucleoli and scant to moderate amount of basophilic cytoplasm, lying in sheets and separated by fibrous strands and diffusely infiltrating the ovarian stroma. Fine needle aspiration from breast lump and leg swelling showed predominant population of blast cells. Myeloperoxidase was strongly positive and diagnosis of granulocytic sarcoma was confirmed.

No MeSH data available.


Related in: MedlinePlus