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Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast.

Labbadia F, Salido-Fierréz E, Majado-Martinez J, Cabañas-Perianes V, Moraleda JJ - Hematol Rep (2012)

Bottom Line: The patient presented with anemia unresponsive to erythropoietin treatment.Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood.After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

ABSTRACT
A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

No MeSH data available.


Related in: MedlinePlus

Blood count evolution after treatment with intravenous immunoglobulin.
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Figure 2: Blood count evolution after treatment with intravenous immunoglobulin.

Mentions: With the diagnosis of PRCA due to PVB19, the patient was treated with intravenous immunoglobulin (IVIG) 500 mg/Kg/day, five days. After three days, the Hemoglobin recovered to a level of 10.4 g/dL and the reticulocytes count to 80.100/µL (Figure 2). The neutropenia improved after the withdrawal of Mycofenolate-Mofetil. In January 2011 the hemoglobin was 14.1 g/dL, hematocrit 43%, the leukocyte and platelet counts were normal and the polymerase chain reaction of the virus was negative.


Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast.

Labbadia F, Salido-Fierréz E, Majado-Martinez J, Cabañas-Perianes V, Moraleda JJ - Hematol Rep (2012)

Blood count evolution after treatment with intravenous immunoglobulin.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475939&req=5

Figure 2: Blood count evolution after treatment with intravenous immunoglobulin.
Mentions: With the diagnosis of PRCA due to PVB19, the patient was treated with intravenous immunoglobulin (IVIG) 500 mg/Kg/day, five days. After three days, the Hemoglobin recovered to a level of 10.4 g/dL and the reticulocytes count to 80.100/µL (Figure 2). The neutropenia improved after the withdrawal of Mycofenolate-Mofetil. In January 2011 the hemoglobin was 14.1 g/dL, hematocrit 43%, the leukocyte and platelet counts were normal and the polymerase chain reaction of the virus was negative.

Bottom Line: The patient presented with anemia unresponsive to erythropoietin treatment.Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood.After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

ABSTRACT
A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

No MeSH data available.


Related in: MedlinePlus