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Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast.

Labbadia F, Salido-Fierréz E, Majado-Martinez J, Cabañas-Perianes V, Moraleda JJ - Hematol Rep (2012)

Bottom Line: The patient presented with anemia unresponsive to erythropoietin treatment.Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood.After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

ABSTRACT
A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

No MeSH data available.


Related in: MedlinePlus

Giant proerythroblasts with nuclear inclusions.
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Related In: Results  -  Collection


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Figure 1: Giant proerythroblasts with nuclear inclusions.

Mentions: The Hematology Department was consulted for the assessment of anemia unresponsive to erythropoietin (2000 UI twice a week) and neutropenia. Further investigations were performed. The peripheral blood cytology showed neutropenia without atypical cells and a normocytic-normochromic anemia with anisopoikilocytosis. The diagnosis of PRCA secondary to anti-EPO antibodies was ruled out because of the absence of anti-EPO antibodies. The serology of PVB19 (IgM) and the detection of human parvovirus B19 DNA by real-time qualitative PCR (Nanogen®) in serum were both positive. The bone marrow aspirate revealed a decreased erythropoiesis and giant proerythroblasts with nuclear inclusions characteristic of parvovirus infection (Figure 1). The granulocytic and megakaryocytic series were normal.


Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast.

Labbadia F, Salido-Fierréz E, Majado-Martinez J, Cabañas-Perianes V, Moraleda JJ - Hematol Rep (2012)

Giant proerythroblasts with nuclear inclusions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475939&req=5

Figure 1: Giant proerythroblasts with nuclear inclusions.
Mentions: The Hematology Department was consulted for the assessment of anemia unresponsive to erythropoietin (2000 UI twice a week) and neutropenia. Further investigations were performed. The peripheral blood cytology showed neutropenia without atypical cells and a normocytic-normochromic anemia with anisopoikilocytosis. The diagnosis of PRCA secondary to anti-EPO antibodies was ruled out because of the absence of anti-EPO antibodies. The serology of PVB19 (IgM) and the detection of human parvovirus B19 DNA by real-time qualitative PCR (Nanogen®) in serum were both positive. The bone marrow aspirate revealed a decreased erythropoiesis and giant proerythroblasts with nuclear inclusions characteristic of parvovirus infection (Figure 1). The granulocytic and megakaryocytic series were normal.

Bottom Line: The patient presented with anemia unresponsive to erythropoietin treatment.Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood.After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

View Article: PubMed Central - PubMed

Affiliation: Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.

ABSTRACT
A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

No MeSH data available.


Related in: MedlinePlus