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Combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma patients: a comparison with a historical control group.

Safaee R, Ahmadzadeh A, Sharifian R, Emami A, Yekaninejad MS, Jalili MH, Valizadeh A - Hematol Rep (2012)

Bottom Line: There was no treatment related mortality.Also, the severity of pain was significantly reduced in the intervention group (P=0.033).Our chemotherapy regimen showed a reasonable response in end stage patients with multiple myeloma in terms of disease control, reducing bone pain and improving survival, in addition to reducing toxicity.

View Article: PubMed Central - PubMed

Affiliation: Hematology and Oncology Research Center, Vali-Asr Hospital and.

ABSTRACT
The aim of this study was to design a regimen for refractory multiple myeloma with minimum complications to achieve a reasonable response. Fifteen patients with active multiple myeloma after at least two lines of conventional treatment underwent therapy with our regimen for two cycles. Disease activity was evaluated after the last cycle. Another 15 patients with refractory multiple myelomas that had previously received only supportive therapy and pain management formed a historical control group. The follow-up period was 12 months for each study group. Of the patients receiving therapy, 6.7% achieved a complete response and 26.7% a partial response; overall response rate was 33.3%. Stable disease was achieved in 46.7% and 20% of the patients had progressive disease. There was no treatment related mortality. The hazard rate of death was 0.73 lower in the intervention group than in the historical control group. In the historical control group, 60% had progressive disease and 40% had stable disease; approximately 40% of patients died during the 12-month follow up. Also, the severity of pain was significantly reduced in the intervention group (P=0.033). Our chemotherapy regimen showed a reasonable response in end stage patients with multiple myeloma in terms of disease control, reducing bone pain and improving survival, in addition to reducing toxicity.

No MeSH data available.


Related in: MedlinePlus

Survival curves of patients in the intervention and control groups.
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Related In: Results  -  Collection


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Figure 1: Survival curves of patients in the intervention and control groups.

Mentions: In the intervention group, after three months of follow up, there was no treatment related mortality. After 12 months of follow up, one patient died. In the historical control group, 40% of the patients died during the 12-month follow up. In most cases, mortality was due to disease progression or sepsis (Figure 1).


Combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma patients: a comparison with a historical control group.

Safaee R, Ahmadzadeh A, Sharifian R, Emami A, Yekaninejad MS, Jalili MH, Valizadeh A - Hematol Rep (2012)

Survival curves of patients in the intervention and control groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475936&req=5

Figure 1: Survival curves of patients in the intervention and control groups.
Mentions: In the intervention group, after three months of follow up, there was no treatment related mortality. After 12 months of follow up, one patient died. In the historical control group, 40% of the patients died during the 12-month follow up. In most cases, mortality was due to disease progression or sepsis (Figure 1).

Bottom Line: There was no treatment related mortality.Also, the severity of pain was significantly reduced in the intervention group (P=0.033).Our chemotherapy regimen showed a reasonable response in end stage patients with multiple myeloma in terms of disease control, reducing bone pain and improving survival, in addition to reducing toxicity.

View Article: PubMed Central - PubMed

Affiliation: Hematology and Oncology Research Center, Vali-Asr Hospital and.

ABSTRACT
The aim of this study was to design a regimen for refractory multiple myeloma with minimum complications to achieve a reasonable response. Fifteen patients with active multiple myeloma after at least two lines of conventional treatment underwent therapy with our regimen for two cycles. Disease activity was evaluated after the last cycle. Another 15 patients with refractory multiple myelomas that had previously received only supportive therapy and pain management formed a historical control group. The follow-up period was 12 months for each study group. Of the patients receiving therapy, 6.7% achieved a complete response and 26.7% a partial response; overall response rate was 33.3%. Stable disease was achieved in 46.7% and 20% of the patients had progressive disease. There was no treatment related mortality. The hazard rate of death was 0.73 lower in the intervention group than in the historical control group. In the historical control group, 60% had progressive disease and 40% had stable disease; approximately 40% of patients died during the 12-month follow up. Also, the severity of pain was significantly reduced in the intervention group (P=0.033). Our chemotherapy regimen showed a reasonable response in end stage patients with multiple myeloma in terms of disease control, reducing bone pain and improving survival, in addition to reducing toxicity.

No MeSH data available.


Related in: MedlinePlus