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Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl.

Kota SK, Gayatri K, Pani JP, Meher LK, Kota SK, Modi KD - Indian J Endocrinol Metab (2012)

Bottom Line: Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation.Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone.Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.

No MeSH data available.


Related in: MedlinePlus

Histopathology study of the biopsy specimen revealing characteristic granulosa cell tumor with focal luteinization (H and E, X300)
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Figure 2: Histopathology study of the biopsy specimen revealing characteristic granulosa cell tumor with focal luteinization (H and E, X300)

Mentions: She underwent staging laparotomy. At laparotomy, a bosselated, yellowish, solid, and movable tumor was found to originate in the left ovary, and measured 6 × 5.5 cm. The uterus and right ovary were macroscopically normal. No pelvic adhesion, ascites or findings of dissemination from the malignant ovarian tumor to the omentum or other organs were observed in the abdominal cavity. This confirmed the stage of the tumor to be Federation of Gynecologists and Obstetricians (FIGO) Stage 1a. Histopathological examination of the left ovarian tumor confirmed the diagnosis of granulosa cell tumor with focal luteinization [Figure 2]. The postoperative course was uncomplicated. She was discharged from the hospital without any complications on the fourth day after surgery. Two weeks after surgery, the serum testosterone level was reduced to 40 ng / dL. She had a normal menstruation two months later. Follow-up after three months revealed no abnormality.


Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl.

Kota SK, Gayatri K, Pani JP, Meher LK, Kota SK, Modi KD - Indian J Endocrinol Metab (2012)

Histopathology study of the biopsy specimen revealing characteristic granulosa cell tumor with focal luteinization (H and E, X300)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475918&req=5

Figure 2: Histopathology study of the biopsy specimen revealing characteristic granulosa cell tumor with focal luteinization (H and E, X300)
Mentions: She underwent staging laparotomy. At laparotomy, a bosselated, yellowish, solid, and movable tumor was found to originate in the left ovary, and measured 6 × 5.5 cm. The uterus and right ovary were macroscopically normal. No pelvic adhesion, ascites or findings of dissemination from the malignant ovarian tumor to the omentum or other organs were observed in the abdominal cavity. This confirmed the stage of the tumor to be Federation of Gynecologists and Obstetricians (FIGO) Stage 1a. Histopathological examination of the left ovarian tumor confirmed the diagnosis of granulosa cell tumor with focal luteinization [Figure 2]. The postoperative course was uncomplicated. She was discharged from the hospital without any complications on the fourth day after surgery. Two weeks after surgery, the serum testosterone level was reduced to 40 ng / dL. She had a normal menstruation two months later. Follow-up after three months revealed no abnormality.

Bottom Line: Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation.Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone.Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.

No MeSH data available.


Related in: MedlinePlus