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Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl.

Kota SK, Gayatri K, Pani JP, Meher LK, Kota SK, Modi KD - Indian J Endocrinol Metab (2012)

Bottom Line: Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation.Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone.Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.

No MeSH data available.


Related in: MedlinePlus

Abdominal and pelvic computed tomography scans demonstrating a left ovarian solid mass (5.5 × 5.0 cm) which was well-demarcated, round, homogenous and well-enhanced. No pathologic findings of other pelvic organs, ascites, and lymphatic enlargements were detected
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Figure 1: Abdominal and pelvic computed tomography scans demonstrating a left ovarian solid mass (5.5 × 5.0 cm) which was well-demarcated, round, homogenous and well-enhanced. No pathologic findings of other pelvic organs, ascites, and lymphatic enlargements were detected

Mentions: Transvaginal ultrasound examination demonstrated the presence of a well-defined, solid, movable, and homogenous echoic mass (5.5 × 4.9 cm), originating from the left ovary. No pathological findings were found within the right ovary and uterus. No ascites were detected. Abdominal and pelvic computed tomography (CT) scans revealed a left ovarian solid mass measuring 5.5 × 5.0 cm in diameter [Figure 1]. The mass was well-demarcated, round, homogenous, and well-enhanced. No pathological findings of other pelvic organs, ascites or lymphatic enlargements were detected.


Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl.

Kota SK, Gayatri K, Pani JP, Meher LK, Kota SK, Modi KD - Indian J Endocrinol Metab (2012)

Abdominal and pelvic computed tomography scans demonstrating a left ovarian solid mass (5.5 × 5.0 cm) which was well-demarcated, round, homogenous and well-enhanced. No pathologic findings of other pelvic organs, ascites, and lymphatic enlargements were detected
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475918&req=5

Figure 1: Abdominal and pelvic computed tomography scans demonstrating a left ovarian solid mass (5.5 × 5.0 cm) which was well-demarcated, round, homogenous and well-enhanced. No pathologic findings of other pelvic organs, ascites, and lymphatic enlargements were detected
Mentions: Transvaginal ultrasound examination demonstrated the presence of a well-defined, solid, movable, and homogenous echoic mass (5.5 × 4.9 cm), originating from the left ovary. No pathological findings were found within the right ovary and uterus. No ascites were detected. Abdominal and pelvic computed tomography (CT) scans revealed a left ovarian solid mass measuring 5.5 × 5.0 cm in diameter [Figure 1]. The mass was well-demarcated, round, homogenous, and well-enhanced. No pathological findings of other pelvic organs, ascites or lymphatic enlargements were detected.

Bottom Line: Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation.Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone.Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Medwin Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
A 16-year-old girl presented with primary amenorrhea and excess hair growth on her body and face for the last three years, along with pain and a mass in her lower abdomen for last one year. Examination revealed hirsutism and other virilizing features, with an irregular mass in the lower abdomen corresponding to 16 weeks'gestation. Serum testosterone was 320 ng / dl and ultrasonogram of the pelvis revealed a solid mass of 5 × 4 cm in the left adnexa. Suspecting it to be a virilizing tumor of the left ovary, the patient was subjected to staging laparotomy, which revealed stage 1a ovarian involvement amenable to surgical resection alone. Histopathological examination confirmed the diagnosis of granulosa cell tumor of the ovary. Postoperatively the serum testosterone returned to 40 ng / dl and her menstrual cycle started after two months of surgery.

No MeSH data available.


Related in: MedlinePlus