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Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland.

Valle-Murillo MA, Perez-Diaz I - Indian J Endocrinol Metab (2012)

Bottom Line: A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia.In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy.Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine, Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion, "Salvador Zubiran", Mexico City, Mexico.

ABSTRACT
We report a rare case of an adult with advanced liver failure in the setting of an untreated congenital panhypopituitarism. A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia. In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy. Hormonal evaluation confirmed the absence of anterior hypophyseal hormones and the liver function tests showed derangement of liver function. Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland. In the approach to liver disease, no cause was identified, besides the untreated panhypopituitarism.

No MeSH data available.


Related in: MedlinePlus

T1-weighted magnetic resonance imaging shows a bright spot in suprasellar location corresponding to ectopic posterior pituitary gland (white arrow). The pituitary gland and sella turcica are small (long arrow)
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Figure 2: T1-weighted magnetic resonance imaging shows a bright spot in suprasellar location corresponding to ectopic posterior pituitary gland (white arrow). The pituitary gland and sella turcica are small (long arrow)

Mentions: MRI showed very hypoplastic adenohypophysis, attenuated stalk, and poor development of sella turcica, and T1-weighted image revealed an ectopic hyperintense suprasellar bright spot compatible with ectopic posterior pituitary tissue [Figure 2]. Furthermore, the hand-wrist X-ray showed delayed bone age [Figure 3], and bone densitometry revealed osteoporosis [total T-score −4.5 (spine) and −3.3 (hip)]. There were no alterations in the karyotype (46, XY).


Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland.

Valle-Murillo MA, Perez-Diaz I - Indian J Endocrinol Metab (2012)

T1-weighted magnetic resonance imaging shows a bright spot in suprasellar location corresponding to ectopic posterior pituitary gland (white arrow). The pituitary gland and sella turcica are small (long arrow)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475913&req=5

Figure 2: T1-weighted magnetic resonance imaging shows a bright spot in suprasellar location corresponding to ectopic posterior pituitary gland (white arrow). The pituitary gland and sella turcica are small (long arrow)
Mentions: MRI showed very hypoplastic adenohypophysis, attenuated stalk, and poor development of sella turcica, and T1-weighted image revealed an ectopic hyperintense suprasellar bright spot compatible with ectopic posterior pituitary tissue [Figure 2]. Furthermore, the hand-wrist X-ray showed delayed bone age [Figure 3], and bone densitometry revealed osteoporosis [total T-score −4.5 (spine) and −3.3 (hip)]. There were no alterations in the karyotype (46, XY).

Bottom Line: A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia.In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy.Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine, Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion, "Salvador Zubiran", Mexico City, Mexico.

ABSTRACT
We report a rare case of an adult with advanced liver failure in the setting of an untreated congenital panhypopituitarism. A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia. In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy. Hormonal evaluation confirmed the absence of anterior hypophyseal hormones and the liver function tests showed derangement of liver function. Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland. In the approach to liver disease, no cause was identified, besides the untreated panhypopituitarism.

No MeSH data available.


Related in: MedlinePlus