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Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland.

Valle-Murillo MA, Perez-Diaz I - Indian J Endocrinol Metab (2012)

Bottom Line: A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia.In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy.Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine, Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion, "Salvador Zubiran", Mexico City, Mexico.

ABSTRACT
We report a rare case of an adult with advanced liver failure in the setting of an untreated congenital panhypopituitarism. A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia. In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy. Hormonal evaluation confirmed the absence of anterior hypophyseal hormones and the liver function tests showed derangement of liver function. Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland. In the approach to liver disease, no cause was identified, besides the untreated panhypopituitarism.

No MeSH data available.


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Liver ultrasound using 3.5-MHz transducer. (a) Transverse scan of the right liver lobe shows diffuse surface irregularities (black arrows) and perihepatic free fluid (white arrow). (b) Transverse scan shows enlarged spleen (998 cm3)
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Figure 1: Liver ultrasound using 3.5-MHz transducer. (a) Transverse scan of the right liver lobe shows diffuse surface irregularities (black arrows) and perihepatic free fluid (white arrow). (b) Transverse scan shows enlarged spleen (998 cm3)

Mentions: Liver ultrasound findings were compatible with chronic liver disease, portal hypertension, and ascites [Figure 1]. Upper gastrointestinal endoscopy confirmed portal gastropathy. Patient had no history of endocrine, hepatic, or metabolic disorder. Alcohol abuse, drug intake, viral infection (B and C virus), autoimmune liver disease, and iron overload were all ruled out.


Hepatopathy in an adult, secondary to congenital untreated panhypopituitarism and ectopic posterior pituitary gland.

Valle-Murillo MA, Perez-Diaz I - Indian J Endocrinol Metab (2012)

Liver ultrasound using 3.5-MHz transducer. (a) Transverse scan of the right liver lobe shows diffuse surface irregularities (black arrows) and perihepatic free fluid (white arrow). (b) Transverse scan shows enlarged spleen (998 cm3)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475913&req=5

Figure 1: Liver ultrasound using 3.5-MHz transducer. (a) Transverse scan of the right liver lobe shows diffuse surface irregularities (black arrows) and perihepatic free fluid (white arrow). (b) Transverse scan shows enlarged spleen (998 cm3)
Mentions: Liver ultrasound findings were compatible with chronic liver disease, portal hypertension, and ascites [Figure 1]. Upper gastrointestinal endoscopy confirmed portal gastropathy. Patient had no history of endocrine, hepatic, or metabolic disorder. Alcohol abuse, drug intake, viral infection (B and C virus), autoimmune liver disease, and iron overload were all ruled out.

Bottom Line: A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia.In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy.Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland.

View Article: PubMed Central - PubMed

Affiliation: Internal Medicine, Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion, "Salvador Zubiran", Mexico City, Mexico.

ABSTRACT
We report a rare case of an adult with advanced liver failure in the setting of an untreated congenital panhypopituitarism. A 32-years-old man presented with a newly onset seizure episode secondary to hypoglycemia. In the initial exploration, we found eunuchoid habitus, absence of secondary sexual characteristics, ascites, and hepatic encephalopathy. Hormonal evaluation confirmed the absence of anterior hypophyseal hormones and the liver function tests showed derangement of liver function. Magnetic Resonance Imaging (MRI) showed hypoplastic adenohypophysis and ectopic posterior pituitary gland. In the approach to liver disease, no cause was identified, besides the untreated panhypopituitarism.

No MeSH data available.


Related in: MedlinePlus