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Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus

Treatment algorithm for low rennin hypertension (British Hypertension society)
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Figure 7: Treatment algorithm for low rennin hypertension (British Hypertension society)

Mentions: Resistant hypertension, defined as a failure of three or more concomitant antihypertensive medications, including diuretics, to lower blood pressure below 140/90 mmHg, is a common clinical problem, affecting up to 30% of hypertensives. Low-dose MR-antagonists provide significant additive blood pressure reductions in such patients as approximately 60–70% of resistant patients are generally found to be low-renin. Low-renin resistant patients respond much better to the addition of amiloride/hydroclorothiazide rather than other diuretic combinations that did not include a drug acting on the ENaC. More extensive studies are needed to define more clearly treatment guidelines for resistant hypertension. An algorithm for low-renin essential hypertension treatment is suggested in Figure 7.


Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Treatment algorithm for low rennin hypertension (British Hypertension society)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475896&req=5

Figure 7: Treatment algorithm for low rennin hypertension (British Hypertension society)
Mentions: Resistant hypertension, defined as a failure of three or more concomitant antihypertensive medications, including diuretics, to lower blood pressure below 140/90 mmHg, is a common clinical problem, affecting up to 30% of hypertensives. Low-dose MR-antagonists provide significant additive blood pressure reductions in such patients as approximately 60–70% of resistant patients are generally found to be low-renin. Low-renin resistant patients respond much better to the addition of amiloride/hydroclorothiazide rather than other diuretic combinations that did not include a drug acting on the ENaC. More extensive studies are needed to define more clearly treatment guidelines for resistant hypertension. An algorithm for low-renin essential hypertension treatment is suggested in Figure 7.

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus