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Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus

Sodium chloride cotransporter in distal tubule
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Figure 4: Sodium chloride cotransporter in distal tubule

Mentions: Pseudohypoaldosteronism type II(or Gordon's syndrome) is a rare genetic form of altered renal salt reabsorption. The genetic defect is transmitted as an autosomal dominant trait. It is due to mutations of the genes encoding for two kinases WNK1 and WNK4 (With no lysine kinase) involved in the regulation of ion transport by Thiazide sensitive co transporter in the distal tubule, resulting in an increased reabsorption of sodium and reduced potassium excretion [Figure 4].[20] Patients present with low-renin and normal aldosterone levels. These patients characteristically display high plasma potassium level, hyperchloraemia and metabolic acidosis and therefore have a phenotype that is easily distinguishable from other patients that display normal or low plasma potassium levels.[2122] The hypertensive phenotype is particularly sensitive to thiazide diuretics.


Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Sodium chloride cotransporter in distal tubule
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475896&req=5

Figure 4: Sodium chloride cotransporter in distal tubule
Mentions: Pseudohypoaldosteronism type II(or Gordon's syndrome) is a rare genetic form of altered renal salt reabsorption. The genetic defect is transmitted as an autosomal dominant trait. It is due to mutations of the genes encoding for two kinases WNK1 and WNK4 (With no lysine kinase) involved in the regulation of ion transport by Thiazide sensitive co transporter in the distal tubule, resulting in an increased reabsorption of sodium and reduced potassium excretion [Figure 4].[20] Patients present with low-renin and normal aldosterone levels. These patients characteristically display high plasma potassium level, hyperchloraemia and metabolic acidosis and therefore have a phenotype that is easily distinguishable from other patients that display normal or low plasma potassium levels.[2122] The hypertensive phenotype is particularly sensitive to thiazide diuretics.

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus