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Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus

Epithelial sodium channel in the collecting duct
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Figure 3: Epithelial sodium channel in the collecting duct

Mentions: Liddle's syndrome is a rare autosomal dominant condition in which there is a primary increase in collecting tubule sodium reabsorption and potassium secretion. The cortical collecting tubule contains two cell types: principal cells (65 percent) and intercalated cells. The principal cells have sodium and potassium channels in the luminal (apical) membrane and Na-K-ATPase pumps in the basolateral membrane.The intercalated cells are primarily involved in hydrogen, bicarbonate, and potassium handling. The principal cells contribute to net sodium reabsorption and are the primary site of potassium secretion [Figure 3]. The intercalated cells are primarily involved in hydrogen, bicarbonate, and potassium handling. In Liddle syndrome there is gain of function mutation of the collecting tubule sodium channel, also called the epithelial sodium channel (ENaC) or the amiloride-sensitive sodium channel. ENaC hyperfunction leads to manifestations of mineralocorticoid excess, such as hypertension, hypokalemia (not universal) and metabolic alkalosis. Most patients present at a young age, but some are not detected until adulthood.


Low renin hypertension.

Sahay M, Sahay RK - Indian J Endocrinol Metab (2012)

Epithelial sodium channel in the collecting duct
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475896&req=5

Figure 3: Epithelial sodium channel in the collecting duct
Mentions: Liddle's syndrome is a rare autosomal dominant condition in which there is a primary increase in collecting tubule sodium reabsorption and potassium secretion. The cortical collecting tubule contains two cell types: principal cells (65 percent) and intercalated cells. The principal cells have sodium and potassium channels in the luminal (apical) membrane and Na-K-ATPase pumps in the basolateral membrane.The intercalated cells are primarily involved in hydrogen, bicarbonate, and potassium handling. The principal cells contribute to net sodium reabsorption and are the primary site of potassium secretion [Figure 3]. The intercalated cells are primarily involved in hydrogen, bicarbonate, and potassium handling. In Liddle syndrome there is gain of function mutation of the collecting tubule sodium channel, also called the epithelial sodium channel (ENaC) or the amiloride-sensitive sodium channel. ENaC hyperfunction leads to manifestations of mineralocorticoid excess, such as hypertension, hypokalemia (not universal) and metabolic alkalosis. Most patients present at a young age, but some are not detected until adulthood.

Bottom Line: Low renin hypertension is an important and often underdiagnosed cause of hypertension.It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc.Some forms of essential hypertension are also associated with low renin levels.

View Article: PubMed Central - PubMed

Affiliation: Deparment of Nephrology, Osmania General Hospital, Hyderabad, Andhra Pradesh, India.

ABSTRACT
Low renin hypertension is an important and often underdiagnosed cause of hypertension. It may be associated with high aldosterone levels as in Conn's syndrome or low aldosterone levels as in Liddle syndrome, and syndrome of apparent mineralocorticoid excess, glucocorticoid remediable hypertension etc. Some forms of essential hypertension are also associated with low renin levels. Hypokalemia may be an important finding in low renin hypertension. The aldosterone to renin ratio helps in correct diagnosis. The treatment varies with etiology hence an accurate diagnosis is essential. Aldosterone antagonists play an important role in medical management of some varieties of low renin hypertension.

No MeSH data available.


Related in: MedlinePlus