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Imaging in short stature.

Chaudhary V, Bano S - Indian J Endocrinol Metab (2012)

Bottom Line: Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses.A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality.In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Employees' State Insurance Corporation (ESIC) Model Hospital, Gurgaon, Haryana, India.

ABSTRACT
Short stature can be a sign of disease, disability, and social stigma causing psychological stress. It is important to have an early diagnosis and treatment. Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses. A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality. In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

No MeSH data available.


Related in: MedlinePlus

ACTH secreting pituitary microadenoma in a patient with clinical features of Cushing's disease and increased serum cortisol level. High resolution dynamic contrast enhanced T1W coronal (a) and sagittal (b) images of brain (at 60 seconds) show a small non enhancing (dark) microadenoma (arrow) lateralized to right side of the pituitary gland. The normal pituitary gland shows marked homogenous enhancement
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Figure 7: ACTH secreting pituitary microadenoma in a patient with clinical features of Cushing's disease and increased serum cortisol level. High resolution dynamic contrast enhanced T1W coronal (a) and sagittal (b) images of brain (at 60 seconds) show a small non enhancing (dark) microadenoma (arrow) lateralized to right side of the pituitary gland. The normal pituitary gland shows marked homogenous enhancement

Mentions: Paediatric Cushing's disease (CD) is a rare cause of short stature. ACTH secreting pituitary microadenoma is the most common cause of CD. Clinically, patients have growth failure, weight gain, moon facies, truncal obesity, adrenarchal signs (acne, pubic/axillary hair) and hypertension. Increased serum cortisol level and pituitary MRI demonstrating ACTH-secreting microadenoma [Figure 7] are important diagnostic tests to confirm the clinical suspicion. However, because of co-existence of an ACTH secreting microadenoma and a pituitary incidentaloma, bilateral inferior petrosal sinus sampling (BIPSS) with corticotrophin-releasing hormone (CRH) stimulation test may be needed for preoperative localization of the microadenoma. Transsphenoidal surgery with selective microadenomectomy allows complete remission of hypercotisolism.[23]


Imaging in short stature.

Chaudhary V, Bano S - Indian J Endocrinol Metab (2012)

ACTH secreting pituitary microadenoma in a patient with clinical features of Cushing's disease and increased serum cortisol level. High resolution dynamic contrast enhanced T1W coronal (a) and sagittal (b) images of brain (at 60 seconds) show a small non enhancing (dark) microadenoma (arrow) lateralized to right side of the pituitary gland. The normal pituitary gland shows marked homogenous enhancement
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475891&req=5

Figure 7: ACTH secreting pituitary microadenoma in a patient with clinical features of Cushing's disease and increased serum cortisol level. High resolution dynamic contrast enhanced T1W coronal (a) and sagittal (b) images of brain (at 60 seconds) show a small non enhancing (dark) microadenoma (arrow) lateralized to right side of the pituitary gland. The normal pituitary gland shows marked homogenous enhancement
Mentions: Paediatric Cushing's disease (CD) is a rare cause of short stature. ACTH secreting pituitary microadenoma is the most common cause of CD. Clinically, patients have growth failure, weight gain, moon facies, truncal obesity, adrenarchal signs (acne, pubic/axillary hair) and hypertension. Increased serum cortisol level and pituitary MRI demonstrating ACTH-secreting microadenoma [Figure 7] are important diagnostic tests to confirm the clinical suspicion. However, because of co-existence of an ACTH secreting microadenoma and a pituitary incidentaloma, bilateral inferior petrosal sinus sampling (BIPSS) with corticotrophin-releasing hormone (CRH) stimulation test may be needed for preoperative localization of the microadenoma. Transsphenoidal surgery with selective microadenomectomy allows complete remission of hypercotisolism.[23]

Bottom Line: Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses.A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality.In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Employees' State Insurance Corporation (ESIC) Model Hospital, Gurgaon, Haryana, India.

ABSTRACT
Short stature can be a sign of disease, disability, and social stigma causing psychological stress. It is important to have an early diagnosis and treatment. Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses. A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality. In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

No MeSH data available.


Related in: MedlinePlus