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Imaging in short stature.

Chaudhary V, Bano S - Indian J Endocrinol Metab (2012)

Bottom Line: Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses.A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality.In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Employees' State Insurance Corporation (ESIC) Model Hospital, Gurgaon, Haryana, India.

ABSTRACT
Short stature can be a sign of disease, disability, and social stigma causing psychological stress. It is important to have an early diagnosis and treatment. Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses. A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality. In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

No MeSH data available.


Related in: MedlinePlus

Cystic craniopharyngioma in a young child with panhypopituitarism. Axial T2W (a) and coronal post contrast T1W (b) images show a large complex cystic sellar-suprasellar mass (thick arrow). Note intratumoral calcification (thin arrow) on non-contrast axial computerized tomographic (CT) image (c). Hyperdense cyst on non-contrast CT suggests presence of high protein content within the cyst
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Figure 2: Cystic craniopharyngioma in a young child with panhypopituitarism. Axial T2W (a) and coronal post contrast T1W (b) images show a large complex cystic sellar-suprasellar mass (thick arrow). Note intratumoral calcification (thin arrow) on non-contrast axial computerized tomographic (CT) image (c). Hyperdense cyst on non-contrast CT suggests presence of high protein content within the cyst

Mentions: Congenital hypopituitarism (CHP) is an important cause of short stature (SS). It may present with isolated growth hormone deficiency (IGHD) or multiple pituitary hormone deficiencies (MPHDs). MRI is the modality of choice in evaluation of pituitary-hypothalamic axis (PHA) in children with CHP. The primary role of MRI is to detect tumors of PHA that may require urgent surgical intervention. MRI has a secondary role in identifying PHA related structural abnormalities responsible for IGHD or MPHDs. CNS tumors [Figures 1 and 2] account for ~23% of abnormal findings in patients with growth failure; these include craniopharyngioma, hypothalamic/optic chiasm glioma, hypothalamic hamartoma, pituitary adenoma, germinoma and leukemia/lymphoma. Structural anomalies of PHA causing growth hormonal deficiency include pituitary hypoplasia, pituitary stalk interruption, ectopic posterior pituitary, and empty sella syndrome [Figure 3]. Congenital hypopituitarism (CHP) may also be associated with midline CNS defects [Figures 4 and 5] like anencephaly, holoprosencephaly, septo-optic dysplasias, corpus callosum dysgenesis, agenesis of septum pellucidum and arachnoid cyst. MRI is extremely helpful in selection and management of patients with hypopituitarism by early diagnosis of the evolving pituitary hormone deficiencies.[1920]


Imaging in short stature.

Chaudhary V, Bano S - Indian J Endocrinol Metab (2012)

Cystic craniopharyngioma in a young child with panhypopituitarism. Axial T2W (a) and coronal post contrast T1W (b) images show a large complex cystic sellar-suprasellar mass (thick arrow). Note intratumoral calcification (thin arrow) on non-contrast axial computerized tomographic (CT) image (c). Hyperdense cyst on non-contrast CT suggests presence of high protein content within the cyst
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475891&req=5

Figure 2: Cystic craniopharyngioma in a young child with panhypopituitarism. Axial T2W (a) and coronal post contrast T1W (b) images show a large complex cystic sellar-suprasellar mass (thick arrow). Note intratumoral calcification (thin arrow) on non-contrast axial computerized tomographic (CT) image (c). Hyperdense cyst on non-contrast CT suggests presence of high protein content within the cyst
Mentions: Congenital hypopituitarism (CHP) is an important cause of short stature (SS). It may present with isolated growth hormone deficiency (IGHD) or multiple pituitary hormone deficiencies (MPHDs). MRI is the modality of choice in evaluation of pituitary-hypothalamic axis (PHA) in children with CHP. The primary role of MRI is to detect tumors of PHA that may require urgent surgical intervention. MRI has a secondary role in identifying PHA related structural abnormalities responsible for IGHD or MPHDs. CNS tumors [Figures 1 and 2] account for ~23% of abnormal findings in patients with growth failure; these include craniopharyngioma, hypothalamic/optic chiasm glioma, hypothalamic hamartoma, pituitary adenoma, germinoma and leukemia/lymphoma. Structural anomalies of PHA causing growth hormonal deficiency include pituitary hypoplasia, pituitary stalk interruption, ectopic posterior pituitary, and empty sella syndrome [Figure 3]. Congenital hypopituitarism (CHP) may also be associated with midline CNS defects [Figures 4 and 5] like anencephaly, holoprosencephaly, septo-optic dysplasias, corpus callosum dysgenesis, agenesis of septum pellucidum and arachnoid cyst. MRI is extremely helpful in selection and management of patients with hypopituitarism by early diagnosis of the evolving pituitary hormone deficiencies.[1920]

Bottom Line: Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses.A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality.In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis, Employees' State Insurance Corporation (ESIC) Model Hospital, Gurgaon, Haryana, India.

ABSTRACT
Short stature can be a sign of disease, disability, and social stigma causing psychological stress. It is important to have an early diagnosis and treatment. Short stature may result from skeletal dysplasias, endocrine disorders, may be familial, or may be the result of malnutrition and chronic illnesses. A team effort of the healthcare professionals like pediatricians, endocrinologists, radiologists, and pathologists is required to diagnose, treat and monitor various pathological conditions associated with growth abnormality. In this review, we have discussed the role of imaging in diagnosing and characterizing various pathological conditions associated with short stature.

No MeSH data available.


Related in: MedlinePlus