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Hantavirus pulmonary syndrome in Santa Cruz, Bolivia: outbreak investigation and antibody prevalence study.

Montgomery JM, Blair PJ, Carroll DS, Mills JN, Gianella A, Iihoshi N, Briggiler AM, Felices V, Salazar M, Olson JG, Glabman RA, Bausch DG - PLoS Negl Trop Dis (2012)

Bottom Line: An antibody prevalence study conducted in the region as part of the outbreak investigation showed 45 (9.1%) of 494 persons to be IgG positive, illustrating that hantavirus infection is common in Santa Cruz Department.Precipitation in the months preceding the outbreak was particularly heavy in comparison to other years, suggesting a possible climatic or ecological influence on rodent populations and risk of hantavirus transmission to humans.Hantavirus infection appears to be common in the Santa Cruz Department, but more comprehensive surveillance and field studies are needed to fully understand the epidemiology and risk to humans.

View Article: PubMed Central - PubMed

Affiliation: Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

ABSTRACT
We report the results of an investigation of a small outbreak of hantavirus pulmonary syndrome in 2002 in the Department of Santa Cruz, Bolivia, where the disease had not previously been reported. Two cases were initially reported. The first case was a physician infected with Laguna Negra virus during a weekend visit to his ranch. Four other persons living on the ranch were IgM antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. The second case was a migrant sugarcane worker. Although no sample remained to determine the specific infecting hantavirus, a virus 90% homologous with Río Mamoré virus was previously found in small-eared pygmy rice rats (Oligoryzomys microtis) trapped in the area. An antibody prevalence study conducted in the region as part of the outbreak investigation showed 45 (9.1%) of 494 persons to be IgG positive, illustrating that hantavirus infection is common in Santa Cruz Department. Precipitation in the months preceding the outbreak was particularly heavy in comparison to other years, suggesting a possible climatic or ecological influence on rodent populations and risk of hantavirus transmission to humans. Hantavirus infection appears to be common in the Santa Cruz Department, but more comprehensive surveillance and field studies are needed to fully understand the epidemiology and risk to humans.

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Related in: MedlinePlus

Average monthly precipitation in Santa Cruz de la Sierra, the capital of Santa Cruz Department, comparing the year of the reported hantavirus outbreak (2002) with averages of the preceding and following four years.
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pntd-0001840-g003: Average monthly precipitation in Santa Cruz de la Sierra, the capital of Santa Cruz Department, comparing the year of the reported hantavirus outbreak (2002) with averages of the preceding and following four years.

Mentions: The occurrence of six human hantavirus infections (including both PCR- and IgM-positive cases) in two ecologically disparate areas of Santa Cruz Department within a few months may relate to region-wide climatic or ecological influences resulting in increased rodent populations [29]–[31]. Deviations in precipitation or temperature, sometimes associated with effects on flowering and fruiting or seed-set of particular plants known to be significant sources of food for rodents, have been implicated in other hantavirus outbreaks, although the precise relationship remains ill-defined [32], [33]. Interestingly, precipitation in the city of Santa Cruz in the months prior to the outbreak appeared to be particularly heavy in comparison to other years (Figure 3). The cases occurred at the end of the rainy season at a time of cooler temperatures.


Hantavirus pulmonary syndrome in Santa Cruz, Bolivia: outbreak investigation and antibody prevalence study.

Montgomery JM, Blair PJ, Carroll DS, Mills JN, Gianella A, Iihoshi N, Briggiler AM, Felices V, Salazar M, Olson JG, Glabman RA, Bausch DG - PLoS Negl Trop Dis (2012)

Average monthly precipitation in Santa Cruz de la Sierra, the capital of Santa Cruz Department, comparing the year of the reported hantavirus outbreak (2002) with averages of the preceding and following four years.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475674&req=5

pntd-0001840-g003: Average monthly precipitation in Santa Cruz de la Sierra, the capital of Santa Cruz Department, comparing the year of the reported hantavirus outbreak (2002) with averages of the preceding and following four years.
Mentions: The occurrence of six human hantavirus infections (including both PCR- and IgM-positive cases) in two ecologically disparate areas of Santa Cruz Department within a few months may relate to region-wide climatic or ecological influences resulting in increased rodent populations [29]–[31]. Deviations in precipitation or temperature, sometimes associated with effects on flowering and fruiting or seed-set of particular plants known to be significant sources of food for rodents, have been implicated in other hantavirus outbreaks, although the precise relationship remains ill-defined [32], [33]. Interestingly, precipitation in the city of Santa Cruz in the months prior to the outbreak appeared to be particularly heavy in comparison to other years (Figure 3). The cases occurred at the end of the rainy season at a time of cooler temperatures.

Bottom Line: An antibody prevalence study conducted in the region as part of the outbreak investigation showed 45 (9.1%) of 494 persons to be IgG positive, illustrating that hantavirus infection is common in Santa Cruz Department.Precipitation in the months preceding the outbreak was particularly heavy in comparison to other years, suggesting a possible climatic or ecological influence on rodent populations and risk of hantavirus transmission to humans.Hantavirus infection appears to be common in the Santa Cruz Department, but more comprehensive surveillance and field studies are needed to fully understand the epidemiology and risk to humans.

View Article: PubMed Central - PubMed

Affiliation: Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.

ABSTRACT
We report the results of an investigation of a small outbreak of hantavirus pulmonary syndrome in 2002 in the Department of Santa Cruz, Bolivia, where the disease had not previously been reported. Two cases were initially reported. The first case was a physician infected with Laguna Negra virus during a weekend visit to his ranch. Four other persons living on the ranch were IgM antibody-positive, two of whom were symptomatic for mild hantavirus pulmonary syndrome. The second case was a migrant sugarcane worker. Although no sample remained to determine the specific infecting hantavirus, a virus 90% homologous with Río Mamoré virus was previously found in small-eared pygmy rice rats (Oligoryzomys microtis) trapped in the area. An antibody prevalence study conducted in the region as part of the outbreak investigation showed 45 (9.1%) of 494 persons to be IgG positive, illustrating that hantavirus infection is common in Santa Cruz Department. Precipitation in the months preceding the outbreak was particularly heavy in comparison to other years, suggesting a possible climatic or ecological influence on rodent populations and risk of hantavirus transmission to humans. Hantavirus infection appears to be common in the Santa Cruz Department, but more comprehensive surveillance and field studies are needed to fully understand the epidemiology and risk to humans.

Show MeSH
Related in: MedlinePlus