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Risk factors related with mortality in patient with pulmonary tuberculosis.

Kim CW, Kim SH, Lee SN, Lee SJ, Lee MK, Lee JH, Shin KC, Yong SJ, Lee WY - Tuberc Respir Dis (Seoul) (2012)

Bottom Line: We compared the groups of patients deceased and patients discharged alive with PTB.Mortality was significantly associated with increased values of white blood cells (WBC), blood urine nitrogen (BUN), creatinine, C-reactive protein (CRP), numbers of involved lung field, and length of hospitalization.Also, it was associated with the decreased values of hemoglobin, lymphocyte, sodium, albumin, and cholesterol.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

ABSTRACT

Background: The prevalence rate of pulmonary tuberculosis (PTB) is steadily decreasing in South Korea. However, PTB is a disease with relatively high mortality and morbidity rates throughout Korea. Although there are many studies and statistics about the risk factors of PTB mortality in many countries, there are only a limited number of domestic papers on this topic. The aim of this study is to determine predictive factors for mortality among in-hospital patients associated with PTB.

Methods: From December 2006 to January 2011, we reviewed medical records of 2,122 adult patients diagnosed with tuberculosis at a single tertiary hospital in a suburban area. In this study period, 960 patients were diagnosed with PTB by positive Acid fast bacilli smear and/or mycobacterial culture of the respiratory specimen. We compared the groups of patients deceased and patients discharged alive with PTB. The number of dead patients was 82 (47 males, 35 females).

Results: Mortality was significantly associated with increased values of white blood cells (WBC), blood urine nitrogen (BUN), creatinine, C-reactive protein (CRP), numbers of involved lung field, and length of hospitalization. Also, it was associated with the decreased values of hemoglobin, lymphocyte, sodium, albumin, and cholesterol. Furthermore, admission through the emergency department, initial intensive care unit admission, and drug resistant PTB affected mortality in PTB patients. Independent predictors associated with PTB mortality are BUN, initial intensive care unit care, and admission during treatment of tuberculosis.

Conclusion: In our study, mortality of pulmonary tuberculosis was related with parameters associated with nutritional status, disease severity at the time of admission, and drug resistance.

No MeSH data available.


Related in: MedlinePlus

Diagram of selecting patients. AFB: acid fast bacillus; TB: tuberculosis.
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Figure 1: Diagram of selecting patients. AFB: acid fast bacillus; TB: tuberculosis.

Mentions: We reviewed medical records of 2,340 patients who visited tertiary teaching university hospital, Yonsei University Wonju Christian Hospital, between December 2006 and January 2011, and were diagnosed with TB by International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). Patients with younger than 20 years of age, negative sputum examination results, extra PTB only, nontuberculous mycobacteria and who did not receive TB tests were excluded from the present study. Among 1,021 patients who were diagnosed with PTB, those who were diagnosed through biopsy only were excluded from the present study, and the remaining 960 inpatients diagnosed with PTB through acid fast bacillus (AFB) smear test and mycobacterium culture test were finally selected. Among patients who were admitted to hospital during treatments, or diagnosed with PTB after admission, a total of 82 patients died; 67 died during hospital stay while 15 died during drug treatment after they were discharged (Figure 1). Control group was selected 187 patients by matching age and gender among who were diagnosed with PTB through sputum examination, and were discharged alive from the hospital.


Risk factors related with mortality in patient with pulmonary tuberculosis.

Kim CW, Kim SH, Lee SN, Lee SJ, Lee MK, Lee JH, Shin KC, Yong SJ, Lee WY - Tuberc Respir Dis (Seoul) (2012)

Diagram of selecting patients. AFB: acid fast bacillus; TB: tuberculosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475478&req=5

Figure 1: Diagram of selecting patients. AFB: acid fast bacillus; TB: tuberculosis.
Mentions: We reviewed medical records of 2,340 patients who visited tertiary teaching university hospital, Yonsei University Wonju Christian Hospital, between December 2006 and January 2011, and were diagnosed with TB by International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10). Patients with younger than 20 years of age, negative sputum examination results, extra PTB only, nontuberculous mycobacteria and who did not receive TB tests were excluded from the present study. Among 1,021 patients who were diagnosed with PTB, those who were diagnosed through biopsy only were excluded from the present study, and the remaining 960 inpatients diagnosed with PTB through acid fast bacillus (AFB) smear test and mycobacterium culture test were finally selected. Among patients who were admitted to hospital during treatments, or diagnosed with PTB after admission, a total of 82 patients died; 67 died during hospital stay while 15 died during drug treatment after they were discharged (Figure 1). Control group was selected 187 patients by matching age and gender among who were diagnosed with PTB through sputum examination, and were discharged alive from the hospital.

Bottom Line: We compared the groups of patients deceased and patients discharged alive with PTB.Mortality was significantly associated with increased values of white blood cells (WBC), blood urine nitrogen (BUN), creatinine, C-reactive protein (CRP), numbers of involved lung field, and length of hospitalization.Also, it was associated with the decreased values of hemoglobin, lymphocyte, sodium, albumin, and cholesterol.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

ABSTRACT

Background: The prevalence rate of pulmonary tuberculosis (PTB) is steadily decreasing in South Korea. However, PTB is a disease with relatively high mortality and morbidity rates throughout Korea. Although there are many studies and statistics about the risk factors of PTB mortality in many countries, there are only a limited number of domestic papers on this topic. The aim of this study is to determine predictive factors for mortality among in-hospital patients associated with PTB.

Methods: From December 2006 to January 2011, we reviewed medical records of 2,122 adult patients diagnosed with tuberculosis at a single tertiary hospital in a suburban area. In this study period, 960 patients were diagnosed with PTB by positive Acid fast bacilli smear and/or mycobacterial culture of the respiratory specimen. We compared the groups of patients deceased and patients discharged alive with PTB. The number of dead patients was 82 (47 males, 35 females).

Results: Mortality was significantly associated with increased values of white blood cells (WBC), blood urine nitrogen (BUN), creatinine, C-reactive protein (CRP), numbers of involved lung field, and length of hospitalization. Also, it was associated with the decreased values of hemoglobin, lymphocyte, sodium, albumin, and cholesterol. Furthermore, admission through the emergency department, initial intensive care unit admission, and drug resistant PTB affected mortality in PTB patients. Independent predictors associated with PTB mortality are BUN, initial intensive care unit care, and admission during treatment of tuberculosis.

Conclusion: In our study, mortality of pulmonary tuberculosis was related with parameters associated with nutritional status, disease severity at the time of admission, and drug resistance.

No MeSH data available.


Related in: MedlinePlus