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A Case of Synchronous Lung Adenocarcinoma and Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type.

Jung CY, Kwon KY - Tuberc Respir Dis (Seoul) (2012)

Bottom Line: A 60-year-old woman was referred to our hospital with a pulmonary nodule.The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation.The bronchial lesions were diagnosed as extranodal MZL.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup of non-Hodgkin's lymphoma. Pulmonary extranodal MZL is a rare entity and accounts for less than 0.5% of primary pulmonary malignancies. Only a few cases of simultaneous occurrence of lung cancer and pulmonary extranodal MZL have been reported. A 60-year-old woman was referred to our hospital with a pulmonary nodule. She was diagnosed with lung adenocarcinoma by percutaneous needle biopsy. The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation. The bronchial lesions were diagnosed as extranodal MZL. Although the patient underwent surgical resection for the lung adenocarcinoma, the pulmonary extranodal MZL was left untreated; it was monitored during follow-up visits. To our knowledge, this is the first report of synchronous lung adenocarcinoma and primary extranodal MZL of the main bronchus.

No MeSH data available.


Related in: MedlinePlus

The computed tomography-guided percutaneous needle biopsy specimens of the right lung nodule. (A) Lung tumor tissue shows non-mucinous adenocarcinoma with a lepdic and acinar growth pattern and stromal infiltration. Immunohistochemical stains were positive for (B) cytokeratin (CK) 7 and (C) thyroid transcription factor-1, and negative for (D) CK20 (A~D, ×200).
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Figure 4: The computed tomography-guided percutaneous needle biopsy specimens of the right lung nodule. (A) Lung tumor tissue shows non-mucinous adenocarcinoma with a lepdic and acinar growth pattern and stromal infiltration. Immunohistochemical stains were positive for (B) cytokeratin (CK) 7 and (C) thyroid transcription factor-1, and negative for (D) CK20 (A~D, ×200).

Mentions: The needle biopsy specimens of the right lung nodule showed non-mucinous adenocarcinoma with a lepidic and acinar growth pattern (Figure 4A). Immunohistochemical stains were positive for cytokeratin (CK) 7 and thyroid transcription factor-1, and negative for CK20 (Figure 4B~D). Histopathology of the bronchoscopic biopsy specimens of the left main bronchus lesions showed diffuse proliferation of atypical lymphoid cells beneath the mucosal epithelium (Figure 5A). Immunohistochemical stains showed diffuse strong positive for CD20, and were negative for pan cytokeratin and CD10 (Figure 5B~D). The proliferation fraction (Ki67) was very low (<5%). The bronchial lesion was diagnosed as extranodal MZL. A bone scan and a brain magnetic resonance imaging study found no other abnormal lesion. A gastroduodenoscopy revealed no mucosal abnormality.


A Case of Synchronous Lung Adenocarcinoma and Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Type.

Jung CY, Kwon KY - Tuberc Respir Dis (Seoul) (2012)

The computed tomography-guided percutaneous needle biopsy specimens of the right lung nodule. (A) Lung tumor tissue shows non-mucinous adenocarcinoma with a lepdic and acinar growth pattern and stromal infiltration. Immunohistochemical stains were positive for (B) cytokeratin (CK) 7 and (C) thyroid transcription factor-1, and negative for (D) CK20 (A~D, ×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475473&req=5

Figure 4: The computed tomography-guided percutaneous needle biopsy specimens of the right lung nodule. (A) Lung tumor tissue shows non-mucinous adenocarcinoma with a lepdic and acinar growth pattern and stromal infiltration. Immunohistochemical stains were positive for (B) cytokeratin (CK) 7 and (C) thyroid transcription factor-1, and negative for (D) CK20 (A~D, ×200).
Mentions: The needle biopsy specimens of the right lung nodule showed non-mucinous adenocarcinoma with a lepidic and acinar growth pattern (Figure 4A). Immunohistochemical stains were positive for cytokeratin (CK) 7 and thyroid transcription factor-1, and negative for CK20 (Figure 4B~D). Histopathology of the bronchoscopic biopsy specimens of the left main bronchus lesions showed diffuse proliferation of atypical lymphoid cells beneath the mucosal epithelium (Figure 5A). Immunohistochemical stains showed diffuse strong positive for CD20, and were negative for pan cytokeratin and CD10 (Figure 5B~D). The proliferation fraction (Ki67) was very low (<5%). The bronchial lesion was diagnosed as extranodal MZL. A bone scan and a brain magnetic resonance imaging study found no other abnormal lesion. A gastroduodenoscopy revealed no mucosal abnormality.

Bottom Line: A 60-year-old woman was referred to our hospital with a pulmonary nodule.The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation.The bronchial lesions were diagnosed as extranodal MZL.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup of non-Hodgkin's lymphoma. Pulmonary extranodal MZL is a rare entity and accounts for less than 0.5% of primary pulmonary malignancies. Only a few cases of simultaneous occurrence of lung cancer and pulmonary extranodal MZL have been reported. A 60-year-old woman was referred to our hospital with a pulmonary nodule. She was diagnosed with lung adenocarcinoma by percutaneous needle biopsy. The protrusions into the left main bronchus were found by accident while performing bronchoscopy during lung cancer evaluation. The bronchial lesions were diagnosed as extranodal MZL. Although the patient underwent surgical resection for the lung adenocarcinoma, the pulmonary extranodal MZL was left untreated; it was monitored during follow-up visits. To our knowledge, this is the first report of synchronous lung adenocarcinoma and primary extranodal MZL of the main bronchus.

No MeSH data available.


Related in: MedlinePlus