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Invasive aspergillosis involving the lungs and brain after short period of steroid injection: a case report.

Choi YR, Kim JT, Kim JE, Jung HW, Choe KH, Lee KM, An JY - Tuberc Respir Dis (Seoul) (2012)

Bottom Line: Brain magnetic resonance imagining revealed numerous peripheral thin enhancing cystic nodules in both cerebral hemispheres.We initiated intravenous administration of amphotercin B.However, the patient died after nine days.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungbuk University College of Medicine, Cheongju, Korea.

ABSTRACT
Invasive pulmonary aspergillosis (IPA) has emerged as a severe infection in patients with immunocompromised hosts. However, recently, several IPA cases, without an apparent predisposition to immunodeficiency, has been reported. A 72-year-old woman was admitted for evaluation of general weakness and poor oral intake. She reported no medical history, except for intraarticular injection of a corticosteroid for joint pain for the duration of two months. A chest radiography revealed multiple cavitary nodules in both lungs. Examination of specimens, obtained by percutaneous needle biopsy, led to a diagnosis of invasive aspergillosis. Brain magnetic resonance imagining revealed numerous peripheral thin enhancing cystic nodules in both cerebral hemispheres. We initiated intravenous administration of amphotercin B. However, the patient died after nine days. Here, we report an invasive aspergillosis case, which involves the lungs and brain after a short period of steroid injection.

No MeSH data available.


Related in: MedlinePlus

Histologic finding shows an aggregate of fungal hypae with acute angle branching and rare fruiting body (GMS stain, ×400).
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Figure 4: Histologic finding shows an aggregate of fungal hypae with acute angle branching and rare fruiting body (GMS stain, ×400).

Mentions: On the fifth hospital day, we intravenously administered amphotericin B. However, on the sixth hospital day, she became unconscious, hence, we performed a brain magnetic resonance imaging (MRI) and conducted cerebrospinal fluid (CSF) tapping. The MRI showed numerous thin peripheral enhancing cystic nodules at bilateral cerebral hemispheres (mainly cortex and subcortical white matter), basal ganglia, pons, and midbrain (Figure 4). CSF examination showed non-specific findings. We concluded that the brain was also involved by invasive aspergillosis, and we continued intravenous amphotericin B treatment, but her condition deteriorated daily.


Invasive aspergillosis involving the lungs and brain after short period of steroid injection: a case report.

Choi YR, Kim JT, Kim JE, Jung HW, Choe KH, Lee KM, An JY - Tuberc Respir Dis (Seoul) (2012)

Histologic finding shows an aggregate of fungal hypae with acute angle branching and rare fruiting body (GMS stain, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475467&req=5

Figure 4: Histologic finding shows an aggregate of fungal hypae with acute angle branching and rare fruiting body (GMS stain, ×400).
Mentions: On the fifth hospital day, we intravenously administered amphotericin B. However, on the sixth hospital day, she became unconscious, hence, we performed a brain magnetic resonance imaging (MRI) and conducted cerebrospinal fluid (CSF) tapping. The MRI showed numerous thin peripheral enhancing cystic nodules at bilateral cerebral hemispheres (mainly cortex and subcortical white matter), basal ganglia, pons, and midbrain (Figure 4). CSF examination showed non-specific findings. We concluded that the brain was also involved by invasive aspergillosis, and we continued intravenous amphotericin B treatment, but her condition deteriorated daily.

Bottom Line: Brain magnetic resonance imagining revealed numerous peripheral thin enhancing cystic nodules in both cerebral hemispheres.We initiated intravenous administration of amphotercin B.However, the patient died after nine days.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Chungbuk University College of Medicine, Cheongju, Korea.

ABSTRACT
Invasive pulmonary aspergillosis (IPA) has emerged as a severe infection in patients with immunocompromised hosts. However, recently, several IPA cases, without an apparent predisposition to immunodeficiency, has been reported. A 72-year-old woman was admitted for evaluation of general weakness and poor oral intake. She reported no medical history, except for intraarticular injection of a corticosteroid for joint pain for the duration of two months. A chest radiography revealed multiple cavitary nodules in both lungs. Examination of specimens, obtained by percutaneous needle biopsy, led to a diagnosis of invasive aspergillosis. Brain magnetic resonance imagining revealed numerous peripheral thin enhancing cystic nodules in both cerebral hemispheres. We initiated intravenous administration of amphotercin B. However, the patient died after nine days. Here, we report an invasive aspergillosis case, which involves the lungs and brain after a short period of steroid injection.

No MeSH data available.


Related in: MedlinePlus