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Clinical Characteristics of Pandemic Influenza A (H1N1) 2009 Pediatric Infection in Busan and Gyeongsangnam-do: One Institution.

Lee MC, Kim HY, Kong SG, Kim YM, Park SE, Im YT, Park HJ - Tuberc Respir Dis (Seoul) (2012)

Bottom Line: Likewise the children with neurologic deficits faced a 16 times higher risk (OR, 15.738; CI, 7.961~31.111).The most common complication was pneumonia.The very high risk of severe morbidity in children with asthma or neurologic disease shows the critical importance of targeted vaccine coverage, special awareness and swift care by both guardians and primary care providers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Background: This study investigated the clinical characteristics and risk factors of the severity of pandemic influenza A (H1N1) 2009 infection in pediatric patients in Busan and Gyeongsangnam-do.

Methods: Cases of influenza A (H1N1) 2009 in patients under the age of 18 years, confirmed by reverse transcription polymerase chain reaction, at Pusan National University Hospital and Pusan National University Yangsan Hospital from the last week of August 2009 through the last week of February 2010 were retrospectively analyzed.

Results: Of the 3,777 confirmed cases of influenza A (H1N1) 2009, 2,200 (58.2%) were male and 1,577 (41.8%) were female. The average age of the patients was 8.4±4.8 years. The total cases peaked during 44th to 46th week. Most of the patients were in the 5- to 9-year-old age group. Oseltamivir was administered to 2,959 (78.3%) of the patients. 221 patients (5.9%) were hospitalized, age an average of 6.7±4.5 years. The average duration of hospitalization was 7.4±5.6 days. One hundred cases (45.2%) had pneumonia. Risk factors for hospitalization included male gender, <2 years of age, and underlying disease. Children with asthma were at very high risk of hospitalization, over 20 times the non-asthmatic children (odds ratio [OR], 21.684; confidence interval [CI], 13.295~39.791). Likewise the children with neurologic deficits faced a 16 times higher risk (OR, 15.738; CI, 7.961~31.111). Ten of the patients (4.5%) were admitted to the intensive care unit, and eight (3.6%) required mechanical ventilation.

Conclusion: Of the pediatric patients with pandemic influenza A (H1N1) 2009, most of the patients were in the 5- to 9-year-old age group. Risk factors for hospitalization included male gender, <2 years of age, and underlying disease. The most common complication was pneumonia. The very high risk of severe morbidity in children with asthma or neurologic disease shows the critical importance of targeted vaccine coverage, special awareness and swift care by both guardians and primary care providers.

No MeSH data available.


Related in: MedlinePlus

Distribution of patients with pandemic influenza A (H1N1) 2009 by weeks.
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Figure 1: Distribution of patients with pandemic influenza A (H1N1) 2009 by weeks.

Mentions: In terms of incidence, less than 100 cases per week were reported between the 36th week and the 42nd week of 2009, but the rate abruptly increased from the 43rd week reaching a peak in the 44th~46th week. From the 47th week, the incidence decreased, and the incidence was less than 10 per week since the 2nd week of 2010 (Figure 1). The group of 15~18 of age showed an abrupt increase in incidence in August and September 2009, and a peak in October 2009, while all other groups of less than 14 years of age showed an abrupt increase in incidence in October 2009, and a peak in November 2009 meaning one month delay in the incidence pattern. Particularly, the 5~9 years of age group reported more than 2 times of incidence rate than other groups in November 2009. In and after December 2009, number of patients abruptly decreased in all age groups, but the 4 years and younger age group reported the least decrease rate among other age groups and accordingly, the group showed the largest number of patients during the period (Figure 2).


Clinical Characteristics of Pandemic Influenza A (H1N1) 2009 Pediatric Infection in Busan and Gyeongsangnam-do: One Institution.

Lee MC, Kim HY, Kong SG, Kim YM, Park SE, Im YT, Park HJ - Tuberc Respir Dis (Seoul) (2012)

Distribution of patients with pandemic influenza A (H1N1) 2009 by weeks.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3475461&req=5

Figure 1: Distribution of patients with pandemic influenza A (H1N1) 2009 by weeks.
Mentions: In terms of incidence, less than 100 cases per week were reported between the 36th week and the 42nd week of 2009, but the rate abruptly increased from the 43rd week reaching a peak in the 44th~46th week. From the 47th week, the incidence decreased, and the incidence was less than 10 per week since the 2nd week of 2010 (Figure 1). The group of 15~18 of age showed an abrupt increase in incidence in August and September 2009, and a peak in October 2009, while all other groups of less than 14 years of age showed an abrupt increase in incidence in October 2009, and a peak in November 2009 meaning one month delay in the incidence pattern. Particularly, the 5~9 years of age group reported more than 2 times of incidence rate than other groups in November 2009. In and after December 2009, number of patients abruptly decreased in all age groups, but the 4 years and younger age group reported the least decrease rate among other age groups and accordingly, the group showed the largest number of patients during the period (Figure 2).

Bottom Line: Likewise the children with neurologic deficits faced a 16 times higher risk (OR, 15.738; CI, 7.961~31.111).The most common complication was pneumonia.The very high risk of severe morbidity in children with asthma or neurologic disease shows the critical importance of targeted vaccine coverage, special awareness and swift care by both guardians and primary care providers.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT

Background: This study investigated the clinical characteristics and risk factors of the severity of pandemic influenza A (H1N1) 2009 infection in pediatric patients in Busan and Gyeongsangnam-do.

Methods: Cases of influenza A (H1N1) 2009 in patients under the age of 18 years, confirmed by reverse transcription polymerase chain reaction, at Pusan National University Hospital and Pusan National University Yangsan Hospital from the last week of August 2009 through the last week of February 2010 were retrospectively analyzed.

Results: Of the 3,777 confirmed cases of influenza A (H1N1) 2009, 2,200 (58.2%) were male and 1,577 (41.8%) were female. The average age of the patients was 8.4±4.8 years. The total cases peaked during 44th to 46th week. Most of the patients were in the 5- to 9-year-old age group. Oseltamivir was administered to 2,959 (78.3%) of the patients. 221 patients (5.9%) were hospitalized, age an average of 6.7±4.5 years. The average duration of hospitalization was 7.4±5.6 days. One hundred cases (45.2%) had pneumonia. Risk factors for hospitalization included male gender, <2 years of age, and underlying disease. Children with asthma were at very high risk of hospitalization, over 20 times the non-asthmatic children (odds ratio [OR], 21.684; confidence interval [CI], 13.295~39.791). Likewise the children with neurologic deficits faced a 16 times higher risk (OR, 15.738; CI, 7.961~31.111). Ten of the patients (4.5%) were admitted to the intensive care unit, and eight (3.6%) required mechanical ventilation.

Conclusion: Of the pediatric patients with pandemic influenza A (H1N1) 2009, most of the patients were in the 5- to 9-year-old age group. Risk factors for hospitalization included male gender, <2 years of age, and underlying disease. The most common complication was pneumonia. The very high risk of severe morbidity in children with asthma or neurologic disease shows the critical importance of targeted vaccine coverage, special awareness and swift care by both guardians and primary care providers.

No MeSH data available.


Related in: MedlinePlus