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MtDNA analysis of global populations support that major population expansions began before Neolithic Time.

Zheng HX, Yan S, Qin ZD, Jin L - Sci Rep (2012)

Bottom Line: With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas.Furthermore, major population expansions were estimated after Last Glacial Maximum but before Neolithic Time, also corresponding to the result of major lineage expansions.Considering results in current and previous study, global mtDNA evidence showed that rising temperature after Last Glacial Maximum offered amiable environments and might be the most important factor for prehistorical human expansions.

View Article: PubMed Central - PubMed

Affiliation: MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

ABSTRACT
Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From these random samples, we identified the expansion lineages and reconstructed the historical demographic variations. In all the three continents, we found that most major lineage expansions (11 out of 15 star lineages in Africa, all autochthonous lineages in Europe and America) coalesced before the first appearance of agriculture. Furthermore, major population expansions were estimated after Last Glacial Maximum but before Neolithic Time, also corresponding to the result of major lineage expansions. Considering results in current and previous study, global mtDNA evidence showed that rising temperature after Last Glacial Maximum offered amiable environments and might be the most important factor for prehistorical human expansions.

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Related in: MedlinePlus

mtDNA Bayesian skyline plot showing the size trend of 10 global populations.The y-axis is the product of maternal effective size and generation time.The x-axis is the time from present in units of years. The thick solid line is the median estimate and the thin lines (blue) show the 95% highest posterior density limits. Detailed settings refer to Methods.
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f2: mtDNA Bayesian skyline plot showing the size trend of 10 global populations.The y-axis is the product of maternal effective size and generation time.The x-axis is the time from present in units of years. The thick solid line is the median estimate and the thin lines (blue) show the 95% highest posterior density limits. Detailed settings refer to Methods.

Mentions: After removing the M and N lineages, we constructed Bayesian Skyline Plots for the 3 populations respectively and jointly, to describe the historical maternal effective variation trends. From the Bayesian Skyline Plots (BSP) (Figure 2) constructed for each population of African ancestry, two populations (ASW and YRI) showed pre-Neolithic population expansions. ASW showed a distinct trend of growth about 20 kya and extend to 5 kya, while YRI also showed a pre-Neolithic expansion after LGM about 15 kya. From the African BSP (Figure 3B), all the African random samples also showed a 5-fold growth at ~15−11 kya, corresponding to expansion haplogroups L0a1a, L1b1a, L1b1a3, L2a1a, L3b1a, L3e1, L3e2a and L3e2b, and subsequently a 2-fold growth ~5−4kya, which might be driven by the Neolithic Revolution. The time of some expansion linages estimated were compared to previous studies161718, showing little difference. In a recent published paper, African L3 lineage was also proved to have a growth peak before 10 kya, which was identical to our observation18.


MtDNA analysis of global populations support that major population expansions began before Neolithic Time.

Zheng HX, Yan S, Qin ZD, Jin L - Sci Rep (2012)

mtDNA Bayesian skyline plot showing the size trend of 10 global populations.The y-axis is the product of maternal effective size and generation time.The x-axis is the time from present in units of years. The thick solid line is the median estimate and the thin lines (blue) show the 95% highest posterior density limits. Detailed settings refer to Methods.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475341&req=5

f2: mtDNA Bayesian skyline plot showing the size trend of 10 global populations.The y-axis is the product of maternal effective size and generation time.The x-axis is the time from present in units of years. The thick solid line is the median estimate and the thin lines (blue) show the 95% highest posterior density limits. Detailed settings refer to Methods.
Mentions: After removing the M and N lineages, we constructed Bayesian Skyline Plots for the 3 populations respectively and jointly, to describe the historical maternal effective variation trends. From the Bayesian Skyline Plots (BSP) (Figure 2) constructed for each population of African ancestry, two populations (ASW and YRI) showed pre-Neolithic population expansions. ASW showed a distinct trend of growth about 20 kya and extend to 5 kya, while YRI also showed a pre-Neolithic expansion after LGM about 15 kya. From the African BSP (Figure 3B), all the African random samples also showed a 5-fold growth at ~15−11 kya, corresponding to expansion haplogroups L0a1a, L1b1a, L1b1a3, L2a1a, L3b1a, L3e1, L3e2a and L3e2b, and subsequently a 2-fold growth ~5−4kya, which might be driven by the Neolithic Revolution. The time of some expansion linages estimated were compared to previous studies161718, showing little difference. In a recent published paper, African L3 lineage was also proved to have a growth peak before 10 kya, which was identical to our observation18.

Bottom Line: With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas.Furthermore, major population expansions were estimated after Last Glacial Maximum but before Neolithic Time, also corresponding to the result of major lineage expansions.Considering results in current and previous study, global mtDNA evidence showed that rising temperature after Last Glacial Maximum offered amiable environments and might be the most important factor for prehistorical human expansions.

View Article: PubMed Central - PubMed

Affiliation: MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

ABSTRACT
Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From these random samples, we identified the expansion lineages and reconstructed the historical demographic variations. In all the three continents, we found that most major lineage expansions (11 out of 15 star lineages in Africa, all autochthonous lineages in Europe and America) coalesced before the first appearance of agriculture. Furthermore, major population expansions were estimated after Last Glacial Maximum but before Neolithic Time, also corresponding to the result of major lineage expansions. Considering results in current and previous study, global mtDNA evidence showed that rising temperature after Last Glacial Maximum offered amiable environments and might be the most important factor for prehistorical human expansions.

Show MeSH
Related in: MedlinePlus