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Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan.

Otani M, Honda N, Xia PC, Eguchi K, Ichikawa T, Watanabe T, Yamaguchi K, Nakao K, Yamamoto T - Trop Med Health (2012)

Bottom Line: A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples.The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan.An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

ABSTRACT
Endemic areas of human T-lymphotropic virus type 1 (HTLV-1) have been reported in Japan as well as tropical Africa, Central and South America and Melanesia. The existence of two subgroups, i.e., the transcontinental and Japanese subgroups, was reported in Japan. In the present study, we provide data on the ratio of the two subgroups in each endemic area and infection foci and examine the distribution of HTLV-1 in Japan and neighboring areas. A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples. The subgroup determination was done by RFLP reactions using endonucleases HpaI and HinfI. The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan. An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current.

No MeSH data available.


Related in: MedlinePlus

Ratio of the transcontinental subgroup (grey) to the Japanese subgroup (white) of HTLV-1 cosmopolitan subtype in various localities of East Asia. The data of Nogliki, Kakeroma, Taiwan, Kinmen and Fujian were cited from Syrtsev et al. [10], Eguchi et al. [13], Yang et al. [7], Chen et al. [9] and Wang et al. [11], respectively.
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Figure 1: Ratio of the transcontinental subgroup (grey) to the Japanese subgroup (white) of HTLV-1 cosmopolitan subtype in various localities of East Asia. The data of Nogliki, Kakeroma, Taiwan, Kinmen and Fujian were cited from Syrtsev et al. [10], Eguchi et al. [13], Yang et al. [7], Chen et al. [9] and Wang et al. [11], respectively.

Mentions: All except one of the HTLV-1 isolates from Iwate, Hirado and Kumamoto were determined as the Japanese subgroup, while 20–35% of the isolates from Hokkaido, Kochi, Okinawa and Yaeyama were determined as the transcontinental subgroup (Fig. 1). The electrophoresis profile of two isolates (Hokkaido and Kochi) was consistent with neither the Japanese nor the transcontinental subgroup but similar to the West African/Caribbean subgroup shown by Yang et al. [7]. Thus, these were tentatively treated as “undetermined” in the present paper.


Distribution of Two Subgroups of Human T-Lymphotropic Virus Type 1 (HTLV-1) in Endemic Japan.

Otani M, Honda N, Xia PC, Eguchi K, Ichikawa T, Watanabe T, Yamaguchi K, Nakao K, Yamamoto T - Trop Med Health (2012)

Ratio of the transcontinental subgroup (grey) to the Japanese subgroup (white) of HTLV-1 cosmopolitan subtype in various localities of East Asia. The data of Nogliki, Kakeroma, Taiwan, Kinmen and Fujian were cited from Syrtsev et al. [10], Eguchi et al. [13], Yang et al. [7], Chen et al. [9] and Wang et al. [11], respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475314&req=5

Figure 1: Ratio of the transcontinental subgroup (grey) to the Japanese subgroup (white) of HTLV-1 cosmopolitan subtype in various localities of East Asia. The data of Nogliki, Kakeroma, Taiwan, Kinmen and Fujian were cited from Syrtsev et al. [10], Eguchi et al. [13], Yang et al. [7], Chen et al. [9] and Wang et al. [11], respectively.
Mentions: All except one of the HTLV-1 isolates from Iwate, Hirado and Kumamoto were determined as the Japanese subgroup, while 20–35% of the isolates from Hokkaido, Kochi, Okinawa and Yaeyama were determined as the transcontinental subgroup (Fig. 1). The electrophoresis profile of two isolates (Hokkaido and Kochi) was consistent with neither the Japanese nor the transcontinental subgroup but similar to the West African/Caribbean subgroup shown by Yang et al. [7]. Thus, these were tentatively treated as “undetermined” in the present paper.

Bottom Line: A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples.The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan.An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

ABSTRACT
Endemic areas of human T-lymphotropic virus type 1 (HTLV-1) have been reported in Japan as well as tropical Africa, Central and South America and Melanesia. The existence of two subgroups, i.e., the transcontinental and Japanese subgroups, was reported in Japan. In the present study, we provide data on the ratio of the two subgroups in each endemic area and infection foci and examine the distribution of HTLV-1 in Japan and neighboring areas. A 657 bp fragment of env region of HTLV-1 proviral genome was successfully amplified for 183 HTLV-1 positive DNA samples. The subgroup determination was done by RFLP reactions using endonucleases HpaI and HinfI. The northern part of mainland Kyushu, represented by Hirado and Kumamoto, was monopolized by the Japanese subgroup, while the transcontinental subgroup ranged from 20 to 35% in the Pacific coast areas of Shikoku (Kochi), the Ryukyu Archipelago (Kakeroma and Okinawa) and Taiwan. An interesting finding in the present study is the presence of the transcontinental subgroup in Kochi, suggesting the endemicity of the transcontinental subgroup along the Kuroshio Current.

No MeSH data available.


Related in: MedlinePlus