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Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.

Jeong DE, Artan M, Seo K, Lee SJ - Front Genet (2012)

Bottom Line: Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster.Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation.In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology Pohang, South Korea.

ABSTRACT
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.

No MeSH data available.


C. elegans and D. melanogaster sensory systems influence lifespan. (A)C. elegans chemosensory and thermosensory systems regulate lifespan through hormonal signaling. Specific chemosensory (olfactory or gustatory) neurons promote or limit longevity. Insulin/IGF-1 signaling can mediate this longevity response downstream of chemosensory neurons. Perturbation of thermosensory system accelerates aging at high temperatures by influencing the sterol hormonal signaling pathway. (B) Chemosensory systems regulate D. melanogaster lifespan. Olfaction of nutrient-derived odorants promotes the aging of long-lived D. melanogaster upon dietary restriction (DR). Perturbation of the D. melanogaster olfactory system and inhibition of the CO2-sensing system both prolong lifespan. However, the signaling pathways regulated by D. melanogaster chemosensory systems to influence lifespan are unknown.
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Figure 1: C. elegans and D. melanogaster sensory systems influence lifespan. (A)C. elegans chemosensory and thermosensory systems regulate lifespan through hormonal signaling. Specific chemosensory (olfactory or gustatory) neurons promote or limit longevity. Insulin/IGF-1 signaling can mediate this longevity response downstream of chemosensory neurons. Perturbation of thermosensory system accelerates aging at high temperatures by influencing the sterol hormonal signaling pathway. (B) Chemosensory systems regulate D. melanogaster lifespan. Olfaction of nutrient-derived odorants promotes the aging of long-lived D. melanogaster upon dietary restriction (DR). Perturbation of the D. melanogaster olfactory system and inhibition of the CO2-sensing system both prolong lifespan. However, the signaling pathways regulated by D. melanogaster chemosensory systems to influence lifespan are unknown.

Mentions: The perception of external stimuli and subsequent signal transmission for proper responses are the primary function of sensory neurons. These neurons were assigned another important function after remarkable discoveries in invertebrate model animals that lifespan is actively regulated by sensory neuronal systems. Inhibiting chemosensation modulates lifespan in Caenorhabditis elegans and Drosophila melanogaster, and defects in thermosensation shorten C. elegans lifespan at high temperature (Figure 1). Here, we describe how sensory neuronal systems regulate aging processes in these invertebrate model animals and speculate the implications of these findings with regard to mammalian aging.


Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging.

Jeong DE, Artan M, Seo K, Lee SJ - Front Genet (2012)

C. elegans and D. melanogaster sensory systems influence lifespan. (A)C. elegans chemosensory and thermosensory systems regulate lifespan through hormonal signaling. Specific chemosensory (olfactory or gustatory) neurons promote or limit longevity. Insulin/IGF-1 signaling can mediate this longevity response downstream of chemosensory neurons. Perturbation of thermosensory system accelerates aging at high temperatures by influencing the sterol hormonal signaling pathway. (B) Chemosensory systems regulate D. melanogaster lifespan. Olfaction of nutrient-derived odorants promotes the aging of long-lived D. melanogaster upon dietary restriction (DR). Perturbation of the D. melanogaster olfactory system and inhibition of the CO2-sensing system both prolong lifespan. However, the signaling pathways regulated by D. melanogaster chemosensory systems to influence lifespan are unknown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475297&req=5

Figure 1: C. elegans and D. melanogaster sensory systems influence lifespan. (A)C. elegans chemosensory and thermosensory systems regulate lifespan through hormonal signaling. Specific chemosensory (olfactory or gustatory) neurons promote or limit longevity. Insulin/IGF-1 signaling can mediate this longevity response downstream of chemosensory neurons. Perturbation of thermosensory system accelerates aging at high temperatures by influencing the sterol hormonal signaling pathway. (B) Chemosensory systems regulate D. melanogaster lifespan. Olfaction of nutrient-derived odorants promotes the aging of long-lived D. melanogaster upon dietary restriction (DR). Perturbation of the D. melanogaster olfactory system and inhibition of the CO2-sensing system both prolong lifespan. However, the signaling pathways regulated by D. melanogaster chemosensory systems to influence lifespan are unknown.
Mentions: The perception of external stimuli and subsequent signal transmission for proper responses are the primary function of sensory neurons. These neurons were assigned another important function after remarkable discoveries in invertebrate model animals that lifespan is actively regulated by sensory neuronal systems. Inhibiting chemosensation modulates lifespan in Caenorhabditis elegans and Drosophila melanogaster, and defects in thermosensation shorten C. elegans lifespan at high temperature (Figure 1). Here, we describe how sensory neuronal systems regulate aging processes in these invertebrate model animals and speculate the implications of these findings with regard to mammalian aging.

Bottom Line: Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster.Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation.In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.

View Article: PubMed Central - PubMed

Affiliation: Division of Molecular and Life Science, Pohang University of Science and Technology Pohang, South Korea.

ABSTRACT
Many environmental factors that dynamically change in nature influence various aspects of animal physiology. Animals are equipped with sensory neuronal systems that help them properly sense and respond to environmental factors. Several studies have shown that chemosensory and thermosensory neurons affect the lifespan of invertebrate model animals, including Caenorhabditis elegans and Drosophila melanogaster. Although the mechanisms by which these sensory systems modulate lifespan are incompletely understood, hormonal signaling pathways have been implicated in sensory system-mediated lifespan regulation. In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging.

No MeSH data available.