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Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.

Wang SK, Yeh TT, Duh CY - Mar Drugs (2012)

Bottom Line: In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract.The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data.The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

View Article: PubMed Central - PubMed

Affiliation: Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. skwang@cc.kmu.edu.tw

ABSTRACT
In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

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Octocoral Briareum excavatum.
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marinedrugs-10-02103-f001: Octocoral Briareum excavatum.

Mentions: Human cytomegalovirus (HCMV) is a highly ubiquitous pathogen with a global prevalence of 60%~90% in the human population. For healthy people, HCMV remains a long-term subclinical infection, however, in congenital neonates and in immunocompromised patients the virus can cause severe diseases. Of the FDA approved therapeutic drugs, ganciclovir, foscarnet, and cidofovir are reported to have adverse effects on bone marrow and the kidneys. The continued chemical investigation of octocoral B. excavatum (Figure 1) collected at Orchid Island off Taiwan during August 2008 [5] afforded three new briarane-type diterpenoids, briacavatolides D–F (1–3) (Figure 2) (not to be confused with the related briaexcavatolides). The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cell lines were evaluated.


Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.

Wang SK, Yeh TT, Duh CY - Mar Drugs (2012)

Octocoral Briareum excavatum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475276&req=5

marinedrugs-10-02103-f001: Octocoral Briareum excavatum.
Mentions: Human cytomegalovirus (HCMV) is a highly ubiquitous pathogen with a global prevalence of 60%~90% in the human population. For healthy people, HCMV remains a long-term subclinical infection, however, in congenital neonates and in immunocompromised patients the virus can cause severe diseases. Of the FDA approved therapeutic drugs, ganciclovir, foscarnet, and cidofovir are reported to have adverse effects on bone marrow and the kidneys. The continued chemical investigation of octocoral B. excavatum (Figure 1) collected at Orchid Island off Taiwan during August 2008 [5] afforded three new briarane-type diterpenoids, briacavatolides D–F (1–3) (Figure 2) (not to be confused with the related briaexcavatolides). The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cell lines were evaluated.

Bottom Line: In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract.The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data.The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

View Article: PubMed Central - PubMed

Affiliation: Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. skwang@cc.kmu.edu.tw

ABSTRACT
In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

Show MeSH
Related in: MedlinePlus