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Meroterpenes from endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea.

Mei WL, Zheng B, Zhao YX, Zhong HM, Chen XL, Zeng YB, Dong WH, Huang JL, Proksch P, Dai HF - Mar Drugs (2012)

Bottom Line: Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea.A possible biogenetic pathway of compounds 1-6 was also proposed.All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China. meiwenli@itbb.org.cn

ABSTRACT
Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

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The structures of compounds 1–6.
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marinedrugs-10-01993-f001: The structures of compounds 1–6.

Mentions: Marine-derived fungi have recently become a research focus as one of the richest sources of new and bioactive secondary metabolites in the marine environment [1,2]. The mangrove plant Scyphiphora hydrophyllacea Gaertn. F. (Rubiaceae) growing in tropical and subtropical intertidal habitats is a rich source of new iridoids, which have been found to possess cytotoxic activity [3,4,5,6]. The metabolites produced by endophytic fungi from S. hydrophyllacea collected in Hainan attracted our attention [7], a new fatty acid glycoside and two new meroterpenes have been found from the fungus A1 of S. hydrophyllacea [8,9]. Further phytochemical investigation of the secondary metabolites from the culture broth of the fungus A1 led to the isolation of four new meroterpenes, guignardones F–I (1–4) (Figure 1), and two known compounds, guignardones A (5) and B (6) [10]. This paper reports the isolation and structural elucidation, as well as biological activities and plausible biogenetic pathway of these compounds.


Meroterpenes from endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea.

Mei WL, Zheng B, Zhao YX, Zhong HM, Chen XL, Zeng YB, Dong WH, Huang JL, Proksch P, Dai HF - Mar Drugs (2012)

The structures of compounds 1–6.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475268&req=5

marinedrugs-10-01993-f001: The structures of compounds 1–6.
Mentions: Marine-derived fungi have recently become a research focus as one of the richest sources of new and bioactive secondary metabolites in the marine environment [1,2]. The mangrove plant Scyphiphora hydrophyllacea Gaertn. F. (Rubiaceae) growing in tropical and subtropical intertidal habitats is a rich source of new iridoids, which have been found to possess cytotoxic activity [3,4,5,6]. The metabolites produced by endophytic fungi from S. hydrophyllacea collected in Hainan attracted our attention [7], a new fatty acid glycoside and two new meroterpenes have been found from the fungus A1 of S. hydrophyllacea [8,9]. Further phytochemical investigation of the secondary metabolites from the culture broth of the fungus A1 led to the isolation of four new meroterpenes, guignardones F–I (1–4) (Figure 1), and two known compounds, guignardones A (5) and B (6) [10]. This paper reports the isolation and structural elucidation, as well as biological activities and plausible biogenetic pathway of these compounds.

Bottom Line: Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea.A possible biogenetic pathway of compounds 1-6 was also proposed.All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

View Article: PubMed Central - PubMed

Affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China. meiwenli@itbb.org.cn

ABSTRACT
Four new meroterpenes, guignardones F-I (1-4), together with two known compounds guignardones A (5) and B (6) were isolated from the endophytic fungus A1 of the mangrove plant Scyphiphora hydrophyllacea. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray crystallography. A possible biogenetic pathway of compounds 1-6 was also proposed. All compounds were evaluated for inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus.

Show MeSH
Related in: MedlinePlus