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Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet.

Kobayashi M, Hirahata R, Egusa S, Fukuda M - Nutrients (2012)

Bottom Line: The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group.The plasma total cholesterol level of the F-10 group was significantly decreased.The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Ikebiraki-cho, Nishinomiya, Hyogo, Japan. maki1002@mukogawa-u.ac.jp

ABSTRACT
The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.

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Plasma parameters of rats fed on the experimental diets for 5 weeks. (A) plasma TC level; (B) non-HDL-C; (C) plasma TG level. Each value is the mean ± SE for 8 rats. a,b Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
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nutrients-04-01304-f003: Plasma parameters of rats fed on the experimental diets for 5 weeks. (A) plasma TC level; (B) non-HDL-C; (C) plasma TG level. Each value is the mean ± SE for 8 rats. a,b Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).

Mentions: Plasma TC and non-HDL-C levels in the C group fed a high cholesterol diet were higher compared with those on a cholesterol-free diet in our previous paper [20]. Plasma TG level was slightly lowered by a high cholesterol diet. Plasma TC level was decreased in a dose dependent manner by ingestion of fermented soymilk (Figure 3A). The F-10 group showed a significantly lower TC level from 1 week to 5 weeks. As shown in Figure 3B, plasma non-HDL-C was temporally decreased in a dose dependent manner by ingestion of fermented soymilk from 3 weeks to 4 weeks. The F-10 group displayed significantly decreased non-HDL-C compared with the C group from 1 week to 5 weeks. The HDL-C/TC ratio was significantly increased in the F-10 group compared with the C group (data not shown). Plasma TG level showed temporally significant decrease in the F-10 group from 2 weeks to 4 weeks (Figure 3C).


Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet.

Kobayashi M, Hirahata R, Egusa S, Fukuda M - Nutrients (2012)

Plasma parameters of rats fed on the experimental diets for 5 weeks. (A) plasma TC level; (B) non-HDL-C; (C) plasma TG level. Each value is the mean ± SE for 8 rats. a,b Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475240&req=5

nutrients-04-01304-f003: Plasma parameters of rats fed on the experimental diets for 5 weeks. (A) plasma TC level; (B) non-HDL-C; (C) plasma TG level. Each value is the mean ± SE for 8 rats. a,b Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
Mentions: Plasma TC and non-HDL-C levels in the C group fed a high cholesterol diet were higher compared with those on a cholesterol-free diet in our previous paper [20]. Plasma TG level was slightly lowered by a high cholesterol diet. Plasma TC level was decreased in a dose dependent manner by ingestion of fermented soymilk (Figure 3A). The F-10 group showed a significantly lower TC level from 1 week to 5 weeks. As shown in Figure 3B, plasma non-HDL-C was temporally decreased in a dose dependent manner by ingestion of fermented soymilk from 3 weeks to 4 weeks. The F-10 group displayed significantly decreased non-HDL-C compared with the C group from 1 week to 5 weeks. The HDL-C/TC ratio was significantly increased in the F-10 group compared with the C group (data not shown). Plasma TG level showed temporally significant decrease in the F-10 group from 2 weeks to 4 weeks (Figure 3C).

Bottom Line: The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group.The plasma total cholesterol level of the F-10 group was significantly decreased.The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Ikebiraki-cho, Nishinomiya, Hyogo, Japan. maki1002@mukogawa-u.ac.jp

ABSTRACT
The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.

Show MeSH
Related in: MedlinePlus