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Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet.

Kobayashi M, Hirahata R, Egusa S, Fukuda M - Nutrients (2012)

Bottom Line: The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group.The plasma total cholesterol level of the F-10 group was significantly decreased.The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Ikebiraki-cho, Nishinomiya, Hyogo, Japan. maki1002@mukogawa-u.ac.jp

ABSTRACT
The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.

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Liver parameters of rats fed on the experimental diets for 5 weeks. (A) hepatic cholesterol; (B) hepatic TG; (C) hepatic total lipid. Each value is the mean ± SE for 8 rats. a,b,c Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
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nutrients-04-01304-f002: Liver parameters of rats fed on the experimental diets for 5 weeks. (A) hepatic cholesterol; (B) hepatic TG; (C) hepatic total lipid. Each value is the mean ± SE for 8 rats. a,b,c Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).

Mentions: Hepatic cholesterol and TG levels were higher with a high cholesterol diet compared with those on cholesterol-free diet ingestion in our previous paper [20] and were increased to 13.7-fold and 4.6-fold vs. those on a cholesterol-free diet, respectively. The hepatic cholesterol, TG and total lipid levels in the F-5 and F-10 groups were significantly decreased in a dose dependent manner vs. those of the C group, respectively (Figure 2A,B,C). Furthermore, the hepatic cholesterol, TG and total lipid levels of the F-10 group were significantly decreased compared with those of the F-5 group.


Hypocholesterolemic effects of lactic acid-fermented soymilk on rats fed a high cholesterol diet.

Kobayashi M, Hirahata R, Egusa S, Fukuda M - Nutrients (2012)

Liver parameters of rats fed on the experimental diets for 5 weeks. (A) hepatic cholesterol; (B) hepatic TG; (C) hepatic total lipid. Each value is the mean ± SE for 8 rats. a,b,c Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475240&req=5

nutrients-04-01304-f002: Liver parameters of rats fed on the experimental diets for 5 weeks. (A) hepatic cholesterol; (B) hepatic TG; (C) hepatic total lipid. Each value is the mean ± SE for 8 rats. a,b,c Means not sharing a common superscript differ significantly by Tukey’s multiple-comparison test (p < 0.05).
Mentions: Hepatic cholesterol and TG levels were higher with a high cholesterol diet compared with those on cholesterol-free diet ingestion in our previous paper [20] and were increased to 13.7-fold and 4.6-fold vs. those on a cholesterol-free diet, respectively. The hepatic cholesterol, TG and total lipid levels in the F-5 and F-10 groups were significantly decreased in a dose dependent manner vs. those of the C group, respectively (Figure 2A,B,C). Furthermore, the hepatic cholesterol, TG and total lipid levels of the F-10 group were significantly decreased compared with those of the F-5 group.

Bottom Line: The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group.The plasma total cholesterol level of the F-10 group was significantly decreased.The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased.

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, Ikebiraki-cho, Nishinomiya, Hyogo, Japan. maki1002@mukogawa-u.ac.jp

ABSTRACT
The effect of fermented soymilk on rats fed a high cholesterol diet was investigated to clarify the cholesterol-lowering function. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (1% cholesterol, high cholesterol diet), high cholesterol diet containing 11.7% fermented soymilk diet (5% soy protein as final concentration, F-5), or high cholesterol diet containing 23.4% fermented soymilk diet (10% soy protein as final concentration, F-10) for 5 weeks. The liver weight and fat mass were decreased by the ingestion of fermented soymilk. The hepatic triglyceride and cholesterol levels in the F-5 and F-10 groups were significantly lowered compared to those in the control group. The plasma total cholesterol level of the F-10 group was significantly decreased. The expression of SREBP-2, a cholesterol synthesis-related gene, was significantly decreased in liver of the F-5 group, but the expression of CYP7a1, a cholesterol catabolism-related gene, was significantly increased. These results suggest that fermented soymilk can modulate the cholesterol metabolism in rats fed a high cholesterol diet.

Show MeSH
Related in: MedlinePlus