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Assessing the relationship between vitamin D3 and stratum corneum hydration for the treatment of xerotic skin.

Russell M - Nutrients (2012)

Bottom Line: Eighty three subjects were recruited and blood serum levels and skin conductance measurements were taken after a one week washout.Topical supplementation with cholecalciferol significantly increased measurements of skin moisturization and resulted in improvements in subjective clinical grading of dry skin.Taken together our finding suggest a relationship between serum vitamin D(3) (25(OH)D) levels and hydration of the stratum corneum and further demonstrate the skin moisture benefit from topical application of vitamin D(3).

View Article: PubMed Central - PubMed

Affiliation: Johnson and Johnson Skin Research Center, CPPW, Johnson & Johnson Consumer Companies, Inc., Skillman, NJ 08558, USA. mrusse2@its.jnj.com

ABSTRACT
Vitamin D(3) has been called the "sunshine" vitamin since the formation of vitamin D is mediated by exposure to sunlight. Vitamin D(3) is linked to many health benefits, however serum levels of vitamin D(3) have been decreasing over the last few decades and the lower levels of vitamin D(3) may have consequences on normal physiology. We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and stratum corneum conductance as well as the effect of topical application of cholecalciferol (vitamin D(3)) on dry skin. Eighty three subjects were recruited and blood serum levels and skin conductance measurements were taken after a one week washout. A correlation was observed between vitamin D levels and skin moisture content, individuals with lower levels of vitamin D had lower average skin moisture. Subsequently, a 3-week split leg, randomized, vehicle controlled clinical study was conducted on a subset of 61 of the above individuals who were identified with non-sufficient vitamin D serum levels. Topical supplementation with cholecalciferol significantly increased measurements of skin moisturization and resulted in improvements in subjective clinical grading of dry skin. Taken together our finding suggest a relationship between serum vitamin D(3) (25(OH)D) levels and hydration of the stratum corneum and further demonstrate the skin moisture benefit from topical application of vitamin D(3).

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Subjects were categorized by their vitamin D (OH) serum levels. A statistically significant (ANOVA, p < 0.05) effect of serum 25(OH)D levels and skin conductance was observed. As serum 25(OH)D levels increased, skin conductance also increased.
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nutrients-04-01213-f001: Subjects were categorized by their vitamin D (OH) serum levels. A statistically significant (ANOVA, p < 0.05) effect of serum 25(OH)D levels and skin conductance was observed. As serum 25(OH)D levels increased, skin conductance also increased.

Mentions: Serum 25(OH)D levels ranged from 4.8 to 48.8 ng/mL with 19 subjects classified as deficient (<10 ng/mL), 53 as insufficient (10–30 ng/mL) and 11 subjects as sufficient (>30 ng/mL) based on published literature [5]. A non-invasive measurement was used to assess stratum corneum water content. This instrument measures the high frequency conductance of skin which correlates with skin surface water content [6]. Figure 1 shows that as serum 25(OH)D levels increased, skin conductance also increased (p = 0.02, ANOVA). Mean ± SEM values were 7.9 ± 0.69 μS, 10.7 ± 0.72 μS and 13.0 ± 1.57 μS for deficient, insufficient and sufficient subjects respectively.


Assessing the relationship between vitamin D3 and stratum corneum hydration for the treatment of xerotic skin.

Russell M - Nutrients (2012)

Subjects were categorized by their vitamin D (OH) serum levels. A statistically significant (ANOVA, p < 0.05) effect of serum 25(OH)D levels and skin conductance was observed. As serum 25(OH)D levels increased, skin conductance also increased.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475231&req=5

nutrients-04-01213-f001: Subjects were categorized by their vitamin D (OH) serum levels. A statistically significant (ANOVA, p < 0.05) effect of serum 25(OH)D levels and skin conductance was observed. As serum 25(OH)D levels increased, skin conductance also increased.
Mentions: Serum 25(OH)D levels ranged from 4.8 to 48.8 ng/mL with 19 subjects classified as deficient (<10 ng/mL), 53 as insufficient (10–30 ng/mL) and 11 subjects as sufficient (>30 ng/mL) based on published literature [5]. A non-invasive measurement was used to assess stratum corneum water content. This instrument measures the high frequency conductance of skin which correlates with skin surface water content [6]. Figure 1 shows that as serum 25(OH)D levels increased, skin conductance also increased (p = 0.02, ANOVA). Mean ± SEM values were 7.9 ± 0.69 μS, 10.7 ± 0.72 μS and 13.0 ± 1.57 μS for deficient, insufficient and sufficient subjects respectively.

Bottom Line: Eighty three subjects were recruited and blood serum levels and skin conductance measurements were taken after a one week washout.Topical supplementation with cholecalciferol significantly increased measurements of skin moisturization and resulted in improvements in subjective clinical grading of dry skin.Taken together our finding suggest a relationship between serum vitamin D(3) (25(OH)D) levels and hydration of the stratum corneum and further demonstrate the skin moisture benefit from topical application of vitamin D(3).

View Article: PubMed Central - PubMed

Affiliation: Johnson and Johnson Skin Research Center, CPPW, Johnson & Johnson Consumer Companies, Inc., Skillman, NJ 08558, USA. mrusse2@its.jnj.com

ABSTRACT
Vitamin D(3) has been called the "sunshine" vitamin since the formation of vitamin D is mediated by exposure to sunlight. Vitamin D(3) is linked to many health benefits, however serum levels of vitamin D(3) have been decreasing over the last few decades and the lower levels of vitamin D(3) may have consequences on normal physiology. We investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and stratum corneum conductance as well as the effect of topical application of cholecalciferol (vitamin D(3)) on dry skin. Eighty three subjects were recruited and blood serum levels and skin conductance measurements were taken after a one week washout. A correlation was observed between vitamin D levels and skin moisture content, individuals with lower levels of vitamin D had lower average skin moisture. Subsequently, a 3-week split leg, randomized, vehicle controlled clinical study was conducted on a subset of 61 of the above individuals who were identified with non-sufficient vitamin D serum levels. Topical supplementation with cholecalciferol significantly increased measurements of skin moisturization and resulted in improvements in subjective clinical grading of dry skin. Taken together our finding suggest a relationship between serum vitamin D(3) (25(OH)D) levels and hydration of the stratum corneum and further demonstrate the skin moisture benefit from topical application of vitamin D(3).

Show MeSH
Related in: MedlinePlus