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Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters.

Polyviou TP, Easton C, Beis L, Malkova D, Takas P, Hambly C, Speakman JR, Koehler K, Pitsiladis YP - Nutrients (2012)

Bottom Line: However, the scientific basis of the inclusion of Gly as a "masking agent" remains inconclusive.This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples.In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cardiovascular & Medical Sciences, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK. t.polyviou.1@research.gla.ac.uk

ABSTRACT
Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a "masking agent" remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg(-1) body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) mass determined using the optimized carbon monoxide (CO) rebreathing method pre- and post-supplementation. BM and total body water (TBW) increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 L (BM, P < 0.01; TBW, P <0.01), respectively. This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples. In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.

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Related in: MedlinePlus

Changes in body mass (BM) and total body water (TBW) induced by 7-day supplementation with the hyperhydrating solution containing glycerol (Gly), creatine (Cr) and glucose (Glu). Dashed lines represent mean change of the group and solid black lines represent individual data. Bar charts show Mean ± S.D. values of BM and TBW pre- and post-supplementation, N = 9. * Significant (P < 0.01) difference between pre- and post-supplementation.
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nutrients-04-01171-f003: Changes in body mass (BM) and total body water (TBW) induced by 7-day supplementation with the hyperhydrating solution containing glycerol (Gly), creatine (Cr) and glucose (Glu). Dashed lines represent mean change of the group and solid black lines represent individual data. Bar charts show Mean ± S.D. values of BM and TBW pre- and post-supplementation, N = 9. * Significant (P < 0.01) difference between pre- and post-supplementation.

Mentions: BM and TBW changes are presented in Figure 3. BM and TBW increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 kg (BM, P < 0.01; TBW, P < 0.01; Figure 3), respectively.


Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters.

Polyviou TP, Easton C, Beis L, Malkova D, Takas P, Hambly C, Speakman JR, Koehler K, Pitsiladis YP - Nutrients (2012)

Changes in body mass (BM) and total body water (TBW) induced by 7-day supplementation with the hyperhydrating solution containing glycerol (Gly), creatine (Cr) and glucose (Glu). Dashed lines represent mean change of the group and solid black lines represent individual data. Bar charts show Mean ± S.D. values of BM and TBW pre- and post-supplementation, N = 9. * Significant (P < 0.01) difference between pre- and post-supplementation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475229&req=5

nutrients-04-01171-f003: Changes in body mass (BM) and total body water (TBW) induced by 7-day supplementation with the hyperhydrating solution containing glycerol (Gly), creatine (Cr) and glucose (Glu). Dashed lines represent mean change of the group and solid black lines represent individual data. Bar charts show Mean ± S.D. values of BM and TBW pre- and post-supplementation, N = 9. * Significant (P < 0.01) difference between pre- and post-supplementation.
Mentions: BM and TBW changes are presented in Figure 3. BM and TBW increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 kg (BM, P < 0.01; TBW, P < 0.01; Figure 3), respectively.

Bottom Line: However, the scientific basis of the inclusion of Gly as a "masking agent" remains inconclusive.This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples.In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cardiovascular & Medical Sciences, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK. t.polyviou.1@research.gla.ac.uk

ABSTRACT
Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects. However, the scientific basis of the inclusion of Gly as a "masking agent" remains inconclusive. The purpose of this study was to determine the effects of a hyperhydrating supplement containing Gly on doping-relevant blood parameters. Nine trained males ingested a hyperhydrating mixture twice per day for 7 days containing 1.0 g·kg(-1) body mass (BM) of Gly, 10.0 g of creatine and 75.0 g of glucose. Blood samples were collected and total hemoglobin (Hb) mass determined using the optimized carbon monoxide (CO) rebreathing method pre- and post-supplementation. BM and total body water (TBW) increased significantly following supplementation by 1.1 ± 1.2 and 1.0 ± 1.2 L (BM, P < 0.01; TBW, P <0.01), respectively. This hyperhydration did not significantly alter plasma volume or any of the doping-relevant blood parameters (e.g., hematocrit, Hb, reticulocytes and total Hb-mass) even when Gly was clearly detectable in urine samples. In conclusion, this study shows that supplementation with hyperhydrating solution containing Gly for 7 days does not significantly alter doping-relevant blood parameters.

Show MeSH
Related in: MedlinePlus