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Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus

Glycosylated Porphyrins.
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Figure 18: Glycosylated Porphyrins.

Mentions: Coupling of sugars to photosensitisers has also shown promise in the selective targeting of tumour/diseased cells 9, 125, 149, 150. Tumour cells have high energy requirements and their proliferation is often dependent on glucose uptake - elevated glycolysis rates are observed in cancer cells in comparison to healthy cells. Glucose traverses the cell membrane via receptor mediated endocytosis 125, 149, 150. Porphyrin-saccharide bioconjugates have demonstrated greater binding affinities for cancer cells - cancer cells overexpress glucose transporter receptors 150. Two main types of sugar-porphyrin/PC molecules have been investigated: those where the sugar moiety is attached to the periphery of the porphyrin/PC structure through a linker group and those where the sugar is fused directly to the porphyrin macrocycle 150. A number of research groups have looked at glycosylated porphyrins (figure 18).


Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Glycosylated Porphyrins.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475217&req=5

Figure 18: Glycosylated Porphyrins.
Mentions: Coupling of sugars to photosensitisers has also shown promise in the selective targeting of tumour/diseased cells 9, 125, 149, 150. Tumour cells have high energy requirements and their proliferation is often dependent on glucose uptake - elevated glycolysis rates are observed in cancer cells in comparison to healthy cells. Glucose traverses the cell membrane via receptor mediated endocytosis 125, 149, 150. Porphyrin-saccharide bioconjugates have demonstrated greater binding affinities for cancer cells - cancer cells overexpress glucose transporter receptors 150. Two main types of sugar-porphyrin/PC molecules have been investigated: those where the sugar moiety is attached to the periphery of the porphyrin/PC structure through a linker group and those where the sugar is fused directly to the porphyrin macrocycle 150. A number of research groups have looked at glycosylated porphyrins (figure 18).

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus