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Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus

5,10-Di-(4-sulphonatophenyl)-15,20-diphenylporphyrinato aluminium chloride.
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Related In: Results  -  Collection


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Figure 16: 5,10-Di-(4-sulphonatophenyl)-15,20-diphenylporphyrinato aluminium chloride.

Mentions: The hydrophilic sulphonated porphyrins and PCs (AlPorphyrin and AlPC) have been evaluated for photodynamic activity. The disulphonated analogues (with adjacent substituted sulphonated groups, figure 16) exhibited greater photodynamic activity than their di- (symmetrical), mono-, tri- and tetra-sulphonated counterparts 7, 50, 93.


Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

5,10-Di-(4-sulphonatophenyl)-15,20-diphenylporphyrinato aluminium chloride.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475217&req=5

Figure 16: 5,10-Di-(4-sulphonatophenyl)-15,20-diphenylporphyrinato aluminium chloride.
Mentions: The hydrophilic sulphonated porphyrins and PCs (AlPorphyrin and AlPC) have been evaluated for photodynamic activity. The disulphonated analogues (with adjacent substituted sulphonated groups, figure 16) exhibited greater photodynamic activity than their di- (symmetrical), mono-, tri- and tetra-sulphonated counterparts 7, 50, 93.

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus