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Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus

Naphthalocyanine (NC).
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Figure 14: Naphthalocyanine (NC).

Mentions: Naphthalocyanines (NCs, figure 14) are extended PC derivatives and absorb at even longer wavelengths (740-780nm) than PCs, further increasing the depth photosensitisers could effectively be used at. The absorption region of NCs makes them particularly promising agents for pdt of highly pigmented tumours, such as melanomas, which can present significant problems with the transmission of visible light. The emission from NCs in the near-IR also gives them great potential as in vivo imaging agents. However, NCs are generally less stable than their PC counterparts - they readily decompose in the presence of light and oxygen (two of the vital components for pdt), and metallo-NCs, lacking axial ligands, have a tendency to form H-aggregates in solution; the aggregates are photoinactive. Kenney et al., van Lier et al. and Wöhrle et al. have mainly dominated the research into NC based photosensitisers 4, 7, 75, 76, 91, 104-115.


Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Naphthalocyanine (NC).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475217&req=5

Figure 14: Naphthalocyanine (NC).
Mentions: Naphthalocyanines (NCs, figure 14) are extended PC derivatives and absorb at even longer wavelengths (740-780nm) than PCs, further increasing the depth photosensitisers could effectively be used at. The absorption region of NCs makes them particularly promising agents for pdt of highly pigmented tumours, such as melanomas, which can present significant problems with the transmission of visible light. The emission from NCs in the near-IR also gives them great potential as in vivo imaging agents. However, NCs are generally less stable than their PC counterparts - they readily decompose in the presence of light and oxygen (two of the vital components for pdt), and metallo-NCs, lacking axial ligands, have a tendency to form H-aggregates in solution; the aggregates are photoinactive. Kenney et al., van Lier et al. and Wöhrle et al. have mainly dominated the research into NC based photosensitisers 4, 7, 75, 76, 91, 104-115.

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus