Limits...
Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus

Examples of Non-Porphyrin and Porphyrin Based Photosensitisers.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3475217&req=5

Figure 6: Examples of Non-Porphyrin and Porphyrin Based Photosensitisers.

Mentions: Ideal photosensitisers - although a number of different photosensitising compounds, such as methylene blue (7-(dimethylamino)-N,N-dimethyl-3H-phenothiazin-3-iminium chloride, MB), rose bengal (4,5,6,7-tetrachloro-2′,4′,5′,7′-tetraiodofluorescein disodium salt) and acridine (2,3-benzoquinoline) (figure 6) are known to be efficient singlet oxygen generators (and therefore potential pdt agents) the vast majority of successful pdt photosensitisers are based upon the tetrapyrrole chromophore (figure 1); in particular porphyrin, chlorin, and bacteriochlorin (BC) derivatives (figure 6). These cyclic tetrapyrroles have an inherent similarity to the naturally occurring porphyrins present in living matter - they have no or minimal dark toxicity and, over the years, tetrapyrrolic chemistry has been well researched and developed 3-5, 24, 26, 27, 38-40, 43-52.


Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Examples of Non-Porphyrin and Porphyrin Based Photosensitisers.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475217&req=5

Figure 6: Examples of Non-Porphyrin and Porphyrin Based Photosensitisers.
Mentions: Ideal photosensitisers - although a number of different photosensitising compounds, such as methylene blue (7-(dimethylamino)-N,N-dimethyl-3H-phenothiazin-3-iminium chloride, MB), rose bengal (4,5,6,7-tetrachloro-2′,4′,5′,7′-tetraiodofluorescein disodium salt) and acridine (2,3-benzoquinoline) (figure 6) are known to be efficient singlet oxygen generators (and therefore potential pdt agents) the vast majority of successful pdt photosensitisers are based upon the tetrapyrrole chromophore (figure 1); in particular porphyrin, chlorin, and bacteriochlorin (BC) derivatives (figure 6). These cyclic tetrapyrroles have an inherent similarity to the naturally occurring porphyrins present in living matter - they have no or minimal dark toxicity and, over the years, tetrapyrrolic chemistry has been well researched and developed 3-5, 24, 26, 27, 38-40, 43-52.

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus