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Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus

Photosensitiser Initiated Cell Death.
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Figure 5: Photosensitiser Initiated Cell Death.

Mentions: A photosensitiser is a molecule which when excited by light energy can utilise the irradiating energy to induce photochemical reactions producing lethal cytotoxic agents; these ultimately result in cell death and tissue destruction (figure 5). Photosensitisers are absorbed into cells all over the body and alone are harmless, i.e. in the absence of light and oxygen they have no effect on healthy or abnormal tissue: it is only their activated forms that have a cytotoxic effect 26, 27. Ideally, photosensitisers should be retained by diseased tissue for longer periods of time in comparison to healthy tissue; thus, carefully timed light exposure is vital to ensure photosensitiser activation only occurs once the ratio of photosensitiser in diseased tissue is greater than that present in healthy tissue; thereby minimising unwanted healthy cell damage.


Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Josefsen LB, Boyle RW - Theranostics (2012)

Photosensitiser Initiated Cell Death.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3475217&req=5

Figure 5: Photosensitiser Initiated Cell Death.
Mentions: A photosensitiser is a molecule which when excited by light energy can utilise the irradiating energy to induce photochemical reactions producing lethal cytotoxic agents; these ultimately result in cell death and tissue destruction (figure 5). Photosensitisers are absorbed into cells all over the body and alone are harmless, i.e. in the absence of light and oxygen they have no effect on healthy or abnormal tissue: it is only their activated forms that have a cytotoxic effect 26, 27. Ideally, photosensitisers should be retained by diseased tissue for longer periods of time in comparison to healthy tissue; thus, carefully timed light exposure is vital to ensure photosensitiser activation only occurs once the ratio of photosensitiser in diseased tissue is greater than that present in healthy tissue; thereby minimising unwanted healthy cell damage.

Bottom Line: Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types.Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms.The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.

ABSTRACT
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

No MeSH data available.


Related in: MedlinePlus