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Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women.

Iwamoto M, Imai K, Ohta H, Shirouchi B, Sato M - Lipids Health Dis (2012)

Bottom Line: There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Graduate School of Health and Nutrition Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-Ku, Fukuoka 814-0198, Japan. iwamoto@nakamura-u.ac.jp

ABSTRACT

Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.

Objective: We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels.

Methods: An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women.

Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.

Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

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The chemical structure of β-cryptoxanthin.
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Figure 1: The chemical structure of β-cryptoxanthin.

Mentions: Serum β-cryptoxanthin levels (Figure 1) are lower in overweight subjects than in normal subjects, irrespective of dietary intake [1]. In a case-controlled study, which was part of a larger survey of 2895 subjects with body mass indexes (BMI) greater than 25, serum β-cryptoxanthin levels were found to be lower than in subjects with BMIs lower than 25 [2]. Adipose tissue store excess energy in the form of fat and secretes physiologically active substances known as adipocytokines [3]. Among these compounds, adiponectin is the most abundant adipose-specific protein. Plasma adiponectin levels are negatively correlated with BMI in men and women [4]. Growing evidence suggests that high-molecular weight (HMW)-adiponectin is the most physiologically active form present in metabolic disorders [5]. Plasminogen activator inhibitor-1 (PAI-1) is a non-specific adipocytokine and its levels are positively correlated with the area of visceral fat determined by computed tomography (CT) scan of obese and non-obese subjects [6].


Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women.

Iwamoto M, Imai K, Ohta H, Shirouchi B, Sato M - Lipids Health Dis (2012)

The chemical structure of β-cryptoxanthin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475063&req=5

Figure 1: The chemical structure of β-cryptoxanthin.
Mentions: Serum β-cryptoxanthin levels (Figure 1) are lower in overweight subjects than in normal subjects, irrespective of dietary intake [1]. In a case-controlled study, which was part of a larger survey of 2895 subjects with body mass indexes (BMI) greater than 25, serum β-cryptoxanthin levels were found to be lower than in subjects with BMIs lower than 25 [2]. Adipose tissue store excess energy in the form of fat and secretes physiologically active substances known as adipocytokines [3]. Among these compounds, adiponectin is the most abundant adipose-specific protein. Plasma adiponectin levels are negatively correlated with BMI in men and women [4]. Growing evidence suggests that high-molecular weight (HMW)-adiponectin is the most physiologically active form present in metabolic disorders [5]. Plasminogen activator inhibitor-1 (PAI-1) is a non-specific adipocytokine and its levels are positively correlated with the area of visceral fat determined by computed tomography (CT) scan of obese and non-obese subjects [6].

Bottom Line: There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Graduate School of Health and Nutrition Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jounan-Ku, Fukuoka 814-0198, Japan. iwamoto@nakamura-u.ac.jp

ABSTRACT

Background: Serum β-cryptoxanthin levels are lower in overweight subjects than in normal subjects. Abnormalities of adipocytokine profiles in obesity subjects have been reported. There are several reports that serum β-cryptoxanthin levels in them were relatively lower than normal subjects.

Objective: We hypothesize that supplementation of highly concentrated β-cryptoxanthin improves serum adipocytokine profiles in obese subjects. This study tested the association between β-cryptoxanthin intake and serum adipocytokine levels.

Methods: An intervention study consisted of a 3-week long before-and-after controlled trial, where β-cryptoxanthin (4.7 mg/day) was given to 17 moderately obese postmenopausal women.

Results: The results indicated no significant changes in body weight or body mass index (BMI). Serum β-cryptoxanthin levels increased significantly by 4-fold. Serum high molecular weight (HMW)-adiponectin levels increased significantly, while serum plasminogen activator inhibitor (PAI)-1 levels decreased.

Conclusions: We concluded that increasing the intake of β-cryptoxanthin to approximately 4 mg per day for 3 weeks may have beneficial effects on the serum adipocytokine status and consequently alleviate progression of metabolic syndrome.

Show MeSH
Related in: MedlinePlus