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Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations.

Bruschweiler ED, Danuser B, Huynh CK, Wild P, Schupfer P, Vernez D, Boiteux P, Hopf NB - Front Oncol (2012)

Bottom Line: Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC).Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations.Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

View Article: PubMed Central - PubMed

Affiliation: Institute for Work and Health (IST), University of Lausanne Lausanne, Switzerland.

ABSTRACT
Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC). Wood dust is recognized as a human carcinogen but the specific cancer causative agent remains unknown. One possible explanation is a co-exposure to; wood dust and polycyclic aromatic hydrocarbons (PAHs). PAHs could be generated during incomplete combustion of wood due to heat created by use of power tools. To determine if PAHs are generated from wood during common wood working operations, PAH concentrations in wood dust samples collected in an experimental chamber operated under controlled conditions were analyzed. In addition, personal air samples from workers exposed to wood dust (n = 30) were collected. Wood dust was generated using three different power tools: vibrating sander, belt sander, and saw; and six wood materials: fir, Medium Density Fiberboard (MDF), beech, mahogany, oak and wood melamine. Monitoring of wood workers was carried out by means of personal sampler device during wood working operations. We measured 21 PAH concentrations in wood dust samples by capillary gas chromatography-ion trap mass spectrometry (GC-MS). Total PAH concentrations in wood dust varied greatly (0.24-7.95 ppm) with the lowest being in MDF dust and the highest in wood melamine dust. Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations. Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

No MeSH data available.


Related in: MedlinePlus

Personal inhalable dust concentration (μg/m3) (p-value = 0.02) and BaP concentration (ng/m3) (p-value = 0.06) by operation.
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Figure 3: Personal inhalable dust concentration (μg/m3) (p-value = 0.02) and BaP concentration (ng/m3) (p-value = 0.06) by operation.

Mentions: Personal inhalable dust concentrations varied greatly from 0.88 to 22.9 mg m−3 (n = 30) (GM = 2.8 mg m−3, GSD = 2.5). Overall, “traditional factory workers” (n = 16) were exposed to marginally but not statistically significantly (p-value = 0.38) higher total dust concentration compared to the “modern furniture industry workers” (n = 14) (Table 3). An outlier was observed for inhalable dust concentration with 168.13 mg m−3, which could be explained by projected coarse particles into the CFC sampler. Workplace exposures by operations (sanding, sawing, and other) showed the highest personal inhalable dust concentrations for sawing followed by others and sanding (Figure 3). There was a statistically significant difference in dust concentrations between different operations (p-value = 0.02) (Table 3).


Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations.

Bruschweiler ED, Danuser B, Huynh CK, Wild P, Schupfer P, Vernez D, Boiteux P, Hopf NB - Front Oncol (2012)

Personal inhalable dust concentration (μg/m3) (p-value = 0.02) and BaP concentration (ng/m3) (p-value = 0.06) by operation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475003&req=5

Figure 3: Personal inhalable dust concentration (μg/m3) (p-value = 0.02) and BaP concentration (ng/m3) (p-value = 0.06) by operation.
Mentions: Personal inhalable dust concentrations varied greatly from 0.88 to 22.9 mg m−3 (n = 30) (GM = 2.8 mg m−3, GSD = 2.5). Overall, “traditional factory workers” (n = 16) were exposed to marginally but not statistically significantly (p-value = 0.38) higher total dust concentration compared to the “modern furniture industry workers” (n = 14) (Table 3). An outlier was observed for inhalable dust concentration with 168.13 mg m−3, which could be explained by projected coarse particles into the CFC sampler. Workplace exposures by operations (sanding, sawing, and other) showed the highest personal inhalable dust concentrations for sawing followed by others and sanding (Figure 3). There was a statistically significant difference in dust concentrations between different operations (p-value = 0.02) (Table 3).

Bottom Line: Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC).Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations.Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

View Article: PubMed Central - PubMed

Affiliation: Institute for Work and Health (IST), University of Lausanne Lausanne, Switzerland.

ABSTRACT
Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC). Wood dust is recognized as a human carcinogen but the specific cancer causative agent remains unknown. One possible explanation is a co-exposure to; wood dust and polycyclic aromatic hydrocarbons (PAHs). PAHs could be generated during incomplete combustion of wood due to heat created by use of power tools. To determine if PAHs are generated from wood during common wood working operations, PAH concentrations in wood dust samples collected in an experimental chamber operated under controlled conditions were analyzed. In addition, personal air samples from workers exposed to wood dust (n = 30) were collected. Wood dust was generated using three different power tools: vibrating sander, belt sander, and saw; and six wood materials: fir, Medium Density Fiberboard (MDF), beech, mahogany, oak and wood melamine. Monitoring of wood workers was carried out by means of personal sampler device during wood working operations. We measured 21 PAH concentrations in wood dust samples by capillary gas chromatography-ion trap mass spectrometry (GC-MS). Total PAH concentrations in wood dust varied greatly (0.24-7.95 ppm) with the lowest being in MDF dust and the highest in wood melamine dust. Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations. Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

No MeSH data available.


Related in: MedlinePlus