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Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations.

Bruschweiler ED, Danuser B, Huynh CK, Wild P, Schupfer P, Vernez D, Boiteux P, Hopf NB - Front Oncol (2012)

Bottom Line: Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC).Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations.Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

View Article: PubMed Central - PubMed

Affiliation: Institute for Work and Health (IST), University of Lausanne Lausanne, Switzerland.

ABSTRACT
Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC). Wood dust is recognized as a human carcinogen but the specific cancer causative agent remains unknown. One possible explanation is a co-exposure to; wood dust and polycyclic aromatic hydrocarbons (PAHs). PAHs could be generated during incomplete combustion of wood due to heat created by use of power tools. To determine if PAHs are generated from wood during common wood working operations, PAH concentrations in wood dust samples collected in an experimental chamber operated under controlled conditions were analyzed. In addition, personal air samples from workers exposed to wood dust (n = 30) were collected. Wood dust was generated using three different power tools: vibrating sander, belt sander, and saw; and six wood materials: fir, Medium Density Fiberboard (MDF), beech, mahogany, oak and wood melamine. Monitoring of wood workers was carried out by means of personal sampler device during wood working operations. We measured 21 PAH concentrations in wood dust samples by capillary gas chromatography-ion trap mass spectrometry (GC-MS). Total PAH concentrations in wood dust varied greatly (0.24-7.95 ppm) with the lowest being in MDF dust and the highest in wood melamine dust. Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations. Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

No MeSH data available.


Related in: MedlinePlus

Concentrations of total PAHs (crosses +), BaP (open circles °), Σ6PAHs (filled triangles ▲), and pyrene (x) according to wood material generated during vibration sanding in the exposure chamber. < LOD = below the limit of detection.
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Figure 1: Concentrations of total PAHs (crosses +), BaP (open circles °), Σ6PAHs (filled triangles ▲), and pyrene (x) according to wood material generated during vibration sanding in the exposure chamber. < LOD = below the limit of detection.

Mentions: We observed a difference in total PAH concentrations between the wood materials studied in the experimental chamber (Figure 1). Three samples were obtained for each wood material. The lowest total PAH concentration was measured in MDF dust and contained mainly non-carcinogenic PAHs (fluorene, phenanthrene, fluoranthene, and pyrene). Total PAH concentrations found in dust from beech and sipo, were not significantly different from MDF. The total PAH concentration in fir dust was higher than MDF and contained traces of BaP. Oak dust contained the second highest total PAH concentration, and had quantifiable levels of some carcinogenic PAHs: BaP, benz[a]anthracene, benzo[b]fluoranthene, and benzo[j]fluoranthene. Wood melamine dust contained the highest concentration of total PAHs compared with all other wood materials (MDF, beech, fir, sipo, and oak). Wood melamine differs from the other wood materials as it is a heterogeneous material containing plastic resin and glue. We detected the presence of 21 PAHs, which combined gave the highest concentration of total PAHs for wood melamine. The BaP percentage ([BaP]/[total PAHs] × 100) varied across wood materials with 2.3–3.5% for fir, MDF, oak, and wood melamine; and >1% for sipo and beech. Concentrations for total PAHs, Σ6PAHs, BaP, and pyrene according to wood materials (n = 3 for each wood material) are shown in Figure 1.


Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations.

Bruschweiler ED, Danuser B, Huynh CK, Wild P, Schupfer P, Vernez D, Boiteux P, Hopf NB - Front Oncol (2012)

Concentrations of total PAHs (crosses +), BaP (open circles °), Σ6PAHs (filled triangles ▲), and pyrene (x) according to wood material generated during vibration sanding in the exposure chamber. < LOD = below the limit of detection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3475003&req=5

Figure 1: Concentrations of total PAHs (crosses +), BaP (open circles °), Σ6PAHs (filled triangles ▲), and pyrene (x) according to wood material generated during vibration sanding in the exposure chamber. < LOD = below the limit of detection.
Mentions: We observed a difference in total PAH concentrations between the wood materials studied in the experimental chamber (Figure 1). Three samples were obtained for each wood material. The lowest total PAH concentration was measured in MDF dust and contained mainly non-carcinogenic PAHs (fluorene, phenanthrene, fluoranthene, and pyrene). Total PAH concentrations found in dust from beech and sipo, were not significantly different from MDF. The total PAH concentration in fir dust was higher than MDF and contained traces of BaP. Oak dust contained the second highest total PAH concentration, and had quantifiable levels of some carcinogenic PAHs: BaP, benz[a]anthracene, benzo[b]fluoranthene, and benzo[j]fluoranthene. Wood melamine dust contained the highest concentration of total PAHs compared with all other wood materials (MDF, beech, fir, sipo, and oak). Wood melamine differs from the other wood materials as it is a heterogeneous material containing plastic resin and glue. We detected the presence of 21 PAHs, which combined gave the highest concentration of total PAHs for wood melamine. The BaP percentage ([BaP]/[total PAHs] × 100) varied across wood materials with 2.3–3.5% for fir, MDF, oak, and wood melamine; and >1% for sipo and beech. Concentrations for total PAHs, Σ6PAHs, BaP, and pyrene according to wood materials (n = 3 for each wood material) are shown in Figure 1.

Bottom Line: Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC).Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations.Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

View Article: PubMed Central - PubMed

Affiliation: Institute for Work and Health (IST), University of Lausanne Lausanne, Switzerland.

ABSTRACT
Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC). Wood dust is recognized as a human carcinogen but the specific cancer causative agent remains unknown. One possible explanation is a co-exposure to; wood dust and polycyclic aromatic hydrocarbons (PAHs). PAHs could be generated during incomplete combustion of wood due to heat created by use of power tools. To determine if PAHs are generated from wood during common wood working operations, PAH concentrations in wood dust samples collected in an experimental chamber operated under controlled conditions were analyzed. In addition, personal air samples from workers exposed to wood dust (n = 30) were collected. Wood dust was generated using three different power tools: vibrating sander, belt sander, and saw; and six wood materials: fir, Medium Density Fiberboard (MDF), beech, mahogany, oak and wood melamine. Monitoring of wood workers was carried out by means of personal sampler device during wood working operations. We measured 21 PAH concentrations in wood dust samples by capillary gas chromatography-ion trap mass spectrometry (GC-MS). Total PAH concentrations in wood dust varied greatly (0.24-7.95 ppm) with the lowest being in MDF dust and the highest in wood melamine dust. Personal PAH exposures were between 37.5-119.8 ng m(-3) during wood working operations. Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.

No MeSH data available.


Related in: MedlinePlus