The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
Bottom Line: Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations.Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations.We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. email@example.comShow MeSH
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Mentions: An improved understanding of the specific nanostructural interaction of proteoglycans with polymeric dental materials requires a critical reappraisal of proteoglycans as a biological entity and of their interaction with the collagen fibril surface [13,131] (Fig. 7). Decorin and biglycan, two members of the small leucine-rich repeat (SLRP) family, are the proteoglycans predominantly expressed in dentin . It has been shown that proteoglycans retain a protein core that adopts a folded helical configuration stabilized by hydrogen bonds and hydrophobic and electrostatic interactions , which has also been suggested to bind to four or more collagen microfibrils via an array of hydrogen bonds (particularly decorin) (Fig. 7) .
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. firstname.lastname@example.org