The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
Bottom Line: Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations.Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations.We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: The hybridization of dentin with polymeric bonding agents, originally proposed by Nakabayashi et al. , is a fascinating engineering concept that was conceived to enable the micromechanical retention of synthetic polymers on the complex biological substrate that is the tooth. This concept has since its advent represented the most important and far-reaching revolution in contemporary restorative dentistry. However, since the mechanistic concept of hybridization involves the infiltration of adhesive co-monomers (HEMA, triethyleneglycoldimethacrylate (TEGDMA) and, occasionally, urethane dimethacrylate(UDMA)) into demineralized type I collagen fibrils one may ascertain that this paradigm adopts a simplified perspective of the dentin substrate at the sub-fibrillar level, as schematically depicted in Fig. 4. We contend that these intricate supramolecular interactions in collagen offer a variety of structural, molecular and physical constraints against an improved interaction of the synthetic monomers with the dentin substrate on sub-micrometer scales.
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. email@example.com