The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
Bottom Line: Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations.Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations.We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. email@example.comShow MeSH
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Mentions: Surface features suggestive of the presence of collagen substructural units, commonly described as either microfibrils or subfibrils, have also been identified in dentin. We contend that microfibrils may be a more appropriate nomenclature for these thinner structures, as the features identified as subfibrils by microscopy generally refer to microfibrils earlier identified by XRD studies, which offer a much broader and earlier range of reports. Habelitz et al.  used AFM to report features of about 4 nm in width on the surface of dentin collagen, consistent with the longitudinal microfibrils found in collagen type I of a fully hydrated tendon  (Fig. 2A). These surface features are difficult to quantify but have been reported to wind axially along the fibrils at a shallow angle close to 5° (Fig. 2) [53,54].
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. firstname.lastname@example.org