The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
Bottom Line: Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations.Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations.We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: A feature that distinguishes collagen from other fibrillar macromolecules is that they are most easily recognized by their axial 67 nm periodicity , which can be seen by AFM [37,40] and electron microscopy [10,35,36] and can also be inferred from X-ray diffraction (XRD) data [46–52]. The 67 nm periodicity (corresponding to one D-period) stems from the staggered arrangement of collagen molecules in a given fibril, where the staggered spaces between the ends of successive collagen molecules yield the so-called gap zones and the areas where multiple molecules are superimposed represent the overlap zone (Fig. 1).
Affiliation: Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, NSW, Australia. firstname.lastname@example.org