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Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability.

Saeed S, Tremp AZ, Dessens JT - Mol. Biochem. Parasitol. (2012)

Bottom Line: However, GFP-based fluorescence is dramatically reduced without PbLAP1 present, indicating that PbLAP1 and PbLAP3 interact.Moreover, absence of PbLAP1 markedly reduces the half-life of PbLAP3, consistent with a scenario of misfolding.These findings unveil a potential mechanism of conformational interdependence that facilitates assembly and stability of the functional LCCL protein complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

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Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability.

Saeed S, Tremp AZ, Dessens JT - Mol. Biochem. Parasitol. (2012)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473356&req=5

Bottom Line: However, GFP-based fluorescence is dramatically reduced without PbLAP1 present, indicating that PbLAP1 and PbLAP3 interact.Moreover, absence of PbLAP1 markedly reduces the half-life of PbLAP3, consistent with a scenario of misfolding.These findings unveil a potential mechanism of conformational interdependence that facilitates assembly and stability of the functional LCCL protein complex.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.

Show MeSH
Related in: MedlinePlus