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Relationships between high-sensitive C-reactive protein and markers of arterial stiffness in hypertensive patients. Differences by sex.

Gomez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, Agudo-Conde C, Gomez-Sanchez L, Rodriguez-Sanchez E, Gomez-Sanchez M, Martinez-Vizcaino V, Garcia-Ortiz L - BMC Cardiovasc Disord (2012)

Bottom Line: IMT was greater in men (0.73 ± 0.13 vs 0.69 ± 0.10). hs-CRP was positively correlated to IMT (r=0.261), maximum (r=0.290) and to peripheral AIx (r=0.166) in men, and to PWV in both men (r=0.280) and women (r=0.250).For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, and PWV would increase 0.07 m/sec in men and 0.08 m/sec in women, while central AIx would decrease 2.5 units in women.After adjusting for age, other cardiovascular risk factors and the use of antihypertensive and lipid-lowering drugs, hs-CRP was seen to be positively correlated to carotid IMT in men, and negatively correlated to central AIx in women.

View Article: PubMed Central - HTML - PubMed

Affiliation: Primary Care Research Unit, La Alamedilla Health Center, Avda, Comuneros 27, Salamanca, 37003, Spain. magomez@usal.es

ABSTRACT

Background: The present study was designed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and arterial stiffness according to sex in patients with arterial hypertension.

Methods: A case-series study was carried out in 258 hypertensive patients without antecedents of cardiovascular disease or diabetes mellitus. Nephelometry was used to determine hs-CRP. Office or clinical and home blood pressures were measured with a validated OMRON model M10 sphygmomanometer. Ambulatory blood pressure monitoring was performed with the SpaceLabs 90207 system. Pulse wave velocity (PWV) and central and peripheral augmentation index (AIx) were measured with the SphygmoCor system, and a Sonosite Micromax ultrasound unit was used for automatic measurements of carotid intima-media thickness (IMT). Ambulatory arterial stiffness index and home arterial stiffness index were calculated as "1-slope" from the within-person regression analysis of diastolic-on-systolic ambulatory blood pressure.

Results: Central and peripheral AIx were greater in women than in men: 35.31 ± 9.95 vs 26.59 ± 11.45 and 102.06 ± 20.47 vs 85.97 ± 19.13, respectively. IMT was greater in men (0.73 ± 0.13 vs 0.69 ± 0.10). hs-CRP was positively correlated to IMT (r=0.261), maximum (r=0.290) and to peripheral AIx (r=0.166) in men, and to PWV in both men (r=0.280) and women (r=0.250). In women, hs-CRP was negatively correlated to central AIx (r= -0.222). For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, and PWV would increase 0.07 m/sec in men and 0.08 m/sec in women, while central AIx would decrease 2.5 units in women. In the multiple linear regression analysis, hs-CRP explained 10.2% and 6.7% of PWV variability in women and men, respectively, 8.4% of carotid IMT variability in men, and 4.9% of central AIx variability in women.

Conclusions: After adjusting for age, other cardiovascular risk factors and the use of antihypertensive and lipid-lowering drugs, hs-CRP was seen to be positively correlated to carotid IMT in men, and negatively correlated to central AIx in women. The association of hs-CRP to arterial stiffness parameters differs between men and women.

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Related in: MedlinePlus

Simple linear regression lines, regression equations and r and P values showing the correlations between high-sensitive C-reactive protein and pulse wave velocity, intima media thickness and central augmentation index.
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Figure 1: Simple linear regression lines, regression equations and r and P values showing the correlations between high-sensitive C-reactive protein and pulse wave velocity, intima media thickness and central augmentation index.

Mentions: Figure1 shows the simple linear regression straight lines of hs-CRP as independent variable and IMT maximum, PWV and AIx as dependent variables. For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, with practically no changes in women (β 0.002, p = 0.918), while PWV would increase 0.07 m/sec in men and 0.08 m/sec in women. Lastly, for each unit increase in hs-CRP, the CAIx would decrease 2.5 units in women.


Relationships between high-sensitive C-reactive protein and markers of arterial stiffness in hypertensive patients. Differences by sex.

Gomez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, Agudo-Conde C, Gomez-Sanchez L, Rodriguez-Sanchez E, Gomez-Sanchez M, Martinez-Vizcaino V, Garcia-Ortiz L - BMC Cardiovasc Disord (2012)

Simple linear regression lines, regression equations and r and P values showing the correlations between high-sensitive C-reactive protein and pulse wave velocity, intima media thickness and central augmentation index.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473264&req=5

Figure 1: Simple linear regression lines, regression equations and r and P values showing the correlations between high-sensitive C-reactive protein and pulse wave velocity, intima media thickness and central augmentation index.
Mentions: Figure1 shows the simple linear regression straight lines of hs-CRP as independent variable and IMT maximum, PWV and AIx as dependent variables. For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, with practically no changes in women (β 0.002, p = 0.918), while PWV would increase 0.07 m/sec in men and 0.08 m/sec in women. Lastly, for each unit increase in hs-CRP, the CAIx would decrease 2.5 units in women.

Bottom Line: IMT was greater in men (0.73 ± 0.13 vs 0.69 ± 0.10). hs-CRP was positively correlated to IMT (r=0.261), maximum (r=0.290) and to peripheral AIx (r=0.166) in men, and to PWV in both men (r=0.280) and women (r=0.250).For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, and PWV would increase 0.07 m/sec in men and 0.08 m/sec in women, while central AIx would decrease 2.5 units in women.After adjusting for age, other cardiovascular risk factors and the use of antihypertensive and lipid-lowering drugs, hs-CRP was seen to be positively correlated to carotid IMT in men, and negatively correlated to central AIx in women.

View Article: PubMed Central - HTML - PubMed

Affiliation: Primary Care Research Unit, La Alamedilla Health Center, Avda, Comuneros 27, Salamanca, 37003, Spain. magomez@usal.es

ABSTRACT

Background: The present study was designed to evaluate the relationship between high-sensitivity C-reactive protein (hs-CRP) and arterial stiffness according to sex in patients with arterial hypertension.

Methods: A case-series study was carried out in 258 hypertensive patients without antecedents of cardiovascular disease or diabetes mellitus. Nephelometry was used to determine hs-CRP. Office or clinical and home blood pressures were measured with a validated OMRON model M10 sphygmomanometer. Ambulatory blood pressure monitoring was performed with the SpaceLabs 90207 system. Pulse wave velocity (PWV) and central and peripheral augmentation index (AIx) were measured with the SphygmoCor system, and a Sonosite Micromax ultrasound unit was used for automatic measurements of carotid intima-media thickness (IMT). Ambulatory arterial stiffness index and home arterial stiffness index were calculated as "1-slope" from the within-person regression analysis of diastolic-on-systolic ambulatory blood pressure.

Results: Central and peripheral AIx were greater in women than in men: 35.31 ± 9.95 vs 26.59 ± 11.45 and 102.06 ± 20.47 vs 85.97 ± 19.13, respectively. IMT was greater in men (0.73 ± 0.13 vs 0.69 ± 0.10). hs-CRP was positively correlated to IMT (r=0.261), maximum (r=0.290) and to peripheral AIx (r=0.166) in men, and to PWV in both men (r=0.280) and women (r=0.250). In women, hs-CRP was negatively correlated to central AIx (r= -0.222). For each unit increase in hs-CRP, carotid IMT would increase 0.05 mm in men, and PWV would increase 0.07 m/sec in men and 0.08 m/sec in women, while central AIx would decrease 2.5 units in women. In the multiple linear regression analysis, hs-CRP explained 10.2% and 6.7% of PWV variability in women and men, respectively, 8.4% of carotid IMT variability in men, and 4.9% of central AIx variability in women.

Conclusions: After adjusting for age, other cardiovascular risk factors and the use of antihypertensive and lipid-lowering drugs, hs-CRP was seen to be positively correlated to carotid IMT in men, and negatively correlated to central AIx in women. The association of hs-CRP to arterial stiffness parameters differs between men and women.

Show MeSH
Related in: MedlinePlus