Limits...
18F-2-Deoxy-2-Fluoro-D-Glucose Positron Emission Tomography: Computed Tomography for Preoperative Staging in Gastric Cancer Patients.

Youn SH, Seo KW, Lee SH, Shin YM, Yoon KY - J Gastric Cancer (2012)

Bottom Line: The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity.There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value.Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kosin University College of Medicine, Busan, Korea.

ABSTRACT

Purpose: The use of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography-computed tomography as a routine preoperative modality is increasing for gastric cancer despite controversy with its usefulness in preoperative staging. In this study we aimed to determine the usefulness of preoperative positron emission tomography-computed tomography scans for staging of gastric cancer.

Materials and methods: We retrospectively analyzed 396 patients' positron emission tomography-computed tomography scans acquired for preoperative staging from January to December 2009.

Results: The sensitivity of positron emission tomography-computed tomography for detecting early gastric cancer was 20.7% and it was 74.2% for advanced gastric cancer. The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity. For regional lymph node metastasis, the sensitivity and specificity of the positron emission tomography-computed tomography were 30.7% and 94.7%, respectively. There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value. Fluorodeoxyglucose uptake was detected by positron emission tomography-computed tomography in 24 lesions other than the primary tumors. Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers. Only two cases were detected purely by positron emission tomography-computed tomography.

Conclusions: Positron emission tomography-computed tomography could be useful in detecting metastasis or another primary cancer for preoperative staging in gastric cancer patients, but not for T or N staging. More prospective studies are needed to determine whether positron emission tomography-computed tomography scans should be considered a routine preoperative imaging modality.

No MeSH data available.


Related in: MedlinePlus

Case series of positive FDG uptake in another lesion. (A) Colon. (B) Liver. (C) Lung. (D) Thyroid. (E) Gall bladder. (F) Bone. (G) Other. Four cases in the lung(s), one case in the thyroid, two cases in the gall bladder, two cases in the bone, one case in the breast and one case of cerebellar uptake were observed and progress was evaluated with PET-CT alone. One case of lung uptake and one case of bone uptake were determined to be malignant. op = operation; abd. = abdominal; CT = computed tomography; HCC = hepatocellular carcinoma; Tb = tuberculosis; EBU5 = endobronchial ultrasonography; FNA = fine needle aspiration; F/U = follow-up; GB = gall bladder; R/O = rule out; LADG = laparoscopic assisted distal gastrectomy; PET = positron emission tomography; TCD = transcranial doppler; FDG = fluorodeoxyglucose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3473225&req=5

Figure 3: Case series of positive FDG uptake in another lesion. (A) Colon. (B) Liver. (C) Lung. (D) Thyroid. (E) Gall bladder. (F) Bone. (G) Other. Four cases in the lung(s), one case in the thyroid, two cases in the gall bladder, two cases in the bone, one case in the breast and one case of cerebellar uptake were observed and progress was evaluated with PET-CT alone. One case of lung uptake and one case of bone uptake were determined to be malignant. op = operation; abd. = abdominal; CT = computed tomography; HCC = hepatocellular carcinoma; Tb = tuberculosis; EBU5 = endobronchial ultrasonography; FNA = fine needle aspiration; F/U = follow-up; GB = gall bladder; R/O = rule out; LADG = laparoscopic assisted distal gastrectomy; PET = positron emission tomography; TCD = transcranial doppler; FDG = fluorodeoxyglucose.

Mentions: To summarize, abnormal uptake on PET-CT was observed in 24 of 396 patients for M staging and nine cases were found to have malignant lesions, including primary and metastatic lesions. In 12 cases the lesions were found only on PET-CT without routine preoperative studies. As a result, malignancies were detected in two cases only on PET-CT (Fig. 3).


18F-2-Deoxy-2-Fluoro-D-Glucose Positron Emission Tomography: Computed Tomography for Preoperative Staging in Gastric Cancer Patients.

Youn SH, Seo KW, Lee SH, Shin YM, Yoon KY - J Gastric Cancer (2012)

Case series of positive FDG uptake in another lesion. (A) Colon. (B) Liver. (C) Lung. (D) Thyroid. (E) Gall bladder. (F) Bone. (G) Other. Four cases in the lung(s), one case in the thyroid, two cases in the gall bladder, two cases in the bone, one case in the breast and one case of cerebellar uptake were observed and progress was evaluated with PET-CT alone. One case of lung uptake and one case of bone uptake were determined to be malignant. op = operation; abd. = abdominal; CT = computed tomography; HCC = hepatocellular carcinoma; Tb = tuberculosis; EBU5 = endobronchial ultrasonography; FNA = fine needle aspiration; F/U = follow-up; GB = gall bladder; R/O = rule out; LADG = laparoscopic assisted distal gastrectomy; PET = positron emission tomography; TCD = transcranial doppler; FDG = fluorodeoxyglucose.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473225&req=5

Figure 3: Case series of positive FDG uptake in another lesion. (A) Colon. (B) Liver. (C) Lung. (D) Thyroid. (E) Gall bladder. (F) Bone. (G) Other. Four cases in the lung(s), one case in the thyroid, two cases in the gall bladder, two cases in the bone, one case in the breast and one case of cerebellar uptake were observed and progress was evaluated with PET-CT alone. One case of lung uptake and one case of bone uptake were determined to be malignant. op = operation; abd. = abdominal; CT = computed tomography; HCC = hepatocellular carcinoma; Tb = tuberculosis; EBU5 = endobronchial ultrasonography; FNA = fine needle aspiration; F/U = follow-up; GB = gall bladder; R/O = rule out; LADG = laparoscopic assisted distal gastrectomy; PET = positron emission tomography; TCD = transcranial doppler; FDG = fluorodeoxyglucose.
Mentions: To summarize, abnormal uptake on PET-CT was observed in 24 of 396 patients for M staging and nine cases were found to have malignant lesions, including primary and metastatic lesions. In 12 cases the lesions were found only on PET-CT without routine preoperative studies. As a result, malignancies were detected in two cases only on PET-CT (Fig. 3).

Bottom Line: The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity.There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value.Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Kosin University College of Medicine, Busan, Korea.

ABSTRACT

Purpose: The use of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography-computed tomography as a routine preoperative modality is increasing for gastric cancer despite controversy with its usefulness in preoperative staging. In this study we aimed to determine the usefulness of preoperative positron emission tomography-computed tomography scans for staging of gastric cancer.

Materials and methods: We retrospectively analyzed 396 patients' positron emission tomography-computed tomography scans acquired for preoperative staging from January to December 2009.

Results: The sensitivity of positron emission tomography-computed tomography for detecting early gastric cancer was 20.7% and it was 74.2% for advanced gastric cancer. The size of the primary tumor was correlated with sensitivity, and there was a positive correlation between T stage and sensitivity. For regional lymph node metastasis, the sensitivity and specificity of the positron emission tomography-computed tomography were 30.7% and 94.7%, respectively. There was no correlation between T stage and maximum standardized uptake value or between tumor markers and maximum standardized uptake value. Fluorodeoxyglucose uptake was detected by positron emission tomography-computed tomography in 24 lesions other than the primary tumors. Among them, nine cases were found to be malignant, including double primary cancers and metastatic cancers. Only two cases were detected purely by positron emission tomography-computed tomography.

Conclusions: Positron emission tomography-computed tomography could be useful in detecting metastasis or another primary cancer for preoperative staging in gastric cancer patients, but not for T or N staging. More prospective studies are needed to determine whether positron emission tomography-computed tomography scans should be considered a routine preoperative imaging modality.

No MeSH data available.


Related in: MedlinePlus