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Tumor size as a prognostic factor in gastric cancer patient.

Im WJ, Kim MG, Ha TK, Kwon SJ - J Gastric Cancer (2012)

Bottom Line: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer.When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively.Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: The purpose of this study is to investigate the prognostic significance of tumor size for 5-year survival rate in patients with gastric cancer.

Materials and methods: A total of 1,697 patients with gastric cancer, who underwent potentially curative gastrectomy, were evaluated. Patients were divided into 4 groups as follows, according to the median size of early and advanced gastric cancer, respectively: small early gastric cancer (tumor size ≤3 cm), large early gastric cancer (tumor size >3 cm), small advanced gastric cancer (tumor size ≤6 cm), and large advanced gastric cancer (tumor size >6 cm). The prognostic value of tumor size for 5-year survival rate was investigated.

Results: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer. Multivariate analysis showed that tumor size is an independent prognostic factor for 5-year survival rate in advanced gastric cancer (P=0.003, hazard ratio=1.372, 95% confidence interval=1.115~1.690). When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively.

Conclusions: Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

No MeSH data available.


Related in: MedlinePlus

Survival rate according to tumor size showed significant difference in all cases of advanced gastric cancer (AGC) (P<0.0001), serosa-negative AGC (P<0.0001), and serosa-positive AGC (P<0.0001), respectively.
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Figure 1: Survival rate according to tumor size showed significant difference in all cases of advanced gastric cancer (AGC) (P<0.0001), serosa-negative AGC (P<0.0001), and serosa-positive AGC (P<0.0001), respectively.

Mentions: Statistical significance was observed in the depth of invasion, nodal status, type of surgery, venous invasion, tumor sites, as well as, tumor size, according to the univariate analysis on the prognosis related survival of T2 or T3 group without serosal invasion in AGC (Table 5, Fig. 1).


Tumor size as a prognostic factor in gastric cancer patient.

Im WJ, Kim MG, Ha TK, Kwon SJ - J Gastric Cancer (2012)

Survival rate according to tumor size showed significant difference in all cases of advanced gastric cancer (AGC) (P<0.0001), serosa-negative AGC (P<0.0001), and serosa-positive AGC (P<0.0001), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473223&req=5

Figure 1: Survival rate according to tumor size showed significant difference in all cases of advanced gastric cancer (AGC) (P<0.0001), serosa-negative AGC (P<0.0001), and serosa-positive AGC (P<0.0001), respectively.
Mentions: Statistical significance was observed in the depth of invasion, nodal status, type of surgery, venous invasion, tumor sites, as well as, tumor size, according to the univariate analysis on the prognosis related survival of T2 or T3 group without serosal invasion in AGC (Table 5, Fig. 1).

Bottom Line: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer.When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively.Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: The purpose of this study is to investigate the prognostic significance of tumor size for 5-year survival rate in patients with gastric cancer.

Materials and methods: A total of 1,697 patients with gastric cancer, who underwent potentially curative gastrectomy, were evaluated. Patients were divided into 4 groups as follows, according to the median size of early and advanced gastric cancer, respectively: small early gastric cancer (tumor size ≤3 cm), large early gastric cancer (tumor size >3 cm), small advanced gastric cancer (tumor size ≤6 cm), and large advanced gastric cancer (tumor size >6 cm). The prognostic value of tumor size for 5-year survival rate was investigated.

Results: In a univariate analysis, tumor size is a significant prognostic factor in advanced gastric cancer, but not in early gastric cancer. Multivariate analysis showed that tumor size is an independent prognostic factor for 5-year survival rate in advanced gastric cancer (P=0.003, hazard ratio=1.372, 95% confidence interval=1.115~1.690). When advanced gastric cancer is subdivided into 2 groups, according to serosa invasion: Group 1; serosa negative (T2 and T3, 7th AJCC), and Group 2; serosa positive (T4a and T4b, 7th AJCC), tumor size is an independent prognostic factor in Group 1 (P=0.011, hazard ratio=1.810, 95% confidence interval=1.149~2.852) and in Group 2 (P=0.033, hazard ratio=1.288, 95% confidence interval=1.020~1.627), respectively.

Conclusions: Tumor size is an independent prognostic factor in advanced gastric cancer irrespective of the serosa invasion, but not in early gastric cancer.

No MeSH data available.


Related in: MedlinePlus