Limits...
Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance.

Jung WC, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ, Kim CS - J Gastric Cancer (2012)

Bottom Line: Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion.The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer.

Materials and methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients.

Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).

Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

No MeSH data available.


Related in: MedlinePlus

(A) Overall 3-year survival of gastric cancer patients according to the intercellular adhesion molecule-1 (ICAM-1) immune reactivity. (B) Disease-free 3-year survival of gastric cancer patients according to the ICAM-1 immune reactivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3473220&req=5

Figure 3: (A) Overall 3-year survival of gastric cancer patients according to the intercellular adhesion molecule-1 (ICAM-1) immune reactivity. (B) Disease-free 3-year survival of gastric cancer patients according to the ICAM-1 immune reactivity.

Mentions: In survival analysis, ICAM-1-positive group showed a poor 3-year survival than the ICAM-1-negative group. (54.9% vs. 85.9%) and the disease-free survival result was also the same (Fig. 3).


Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance.

Jung WC, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ, Kim CS - J Gastric Cancer (2012)

(A) Overall 3-year survival of gastric cancer patients according to the intercellular adhesion molecule-1 (ICAM-1) immune reactivity. (B) Disease-free 3-year survival of gastric cancer patients according to the ICAM-1 immune reactivity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473220&req=5

Figure 3: (A) Overall 3-year survival of gastric cancer patients according to the intercellular adhesion molecule-1 (ICAM-1) immune reactivity. (B) Disease-free 3-year survival of gastric cancer patients according to the ICAM-1 immune reactivity.
Mentions: In survival analysis, ICAM-1-positive group showed a poor 3-year survival than the ICAM-1-negative group. (54.9% vs. 85.9%) and the disease-free survival result was also the same (Fig. 3).

Bottom Line: Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion.The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer.

Materials and methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients.

Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).

Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

No MeSH data available.


Related in: MedlinePlus