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Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance.

Jung WC, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ, Kim CS - J Gastric Cancer (2012)

Bottom Line: Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion.The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer.

Materials and methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients.

Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).

Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical staining of intercellular adhesion molecule-1 (ICAM-1), E-selectin in tissue microarray slides of gastric cancer. (A) Expression of ICAM-1 was noted in the endothelial cells of gastric cancer tissues. More than 50% of cancer cells were stained (×400). (B) Expression of E-selectin was noted in the diffuse type signet ring gastric cancer cells. More than 50% were stained (×400).
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Figure 2: Immunohistochemical staining of intercellular adhesion molecule-1 (ICAM-1), E-selectin in tissue microarray slides of gastric cancer. (A) Expression of ICAM-1 was noted in the endothelial cells of gastric cancer tissues. More than 50% of cancer cells were stained (×400). (B) Expression of E-selectin was noted in the diffuse type signet ring gastric cancer cells. More than 50% were stained (×400).

Mentions: From 157 gastric cancer tissues, nearly 50% (n=79) tissues were positive for ICAM-1 and 54% (n=85) were positive for E-selectin by immunohistochemical staining (Fig. 2). There was a reverse relationship between the positivity of ICAM-1 expression and positivity of E-selectin expression (Table 1).


Expression of intercellular adhesion molecule-1 and e-selectin in gastric cancer and their clinical significance.

Jung WC, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ, Kim CS - J Gastric Cancer (2012)

Immunohistochemical staining of intercellular adhesion molecule-1 (ICAM-1), E-selectin in tissue microarray slides of gastric cancer. (A) Expression of ICAM-1 was noted in the endothelial cells of gastric cancer tissues. More than 50% of cancer cells were stained (×400). (B) Expression of E-selectin was noted in the diffuse type signet ring gastric cancer cells. More than 50% were stained (×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3473220&req=5

Figure 2: Immunohistochemical staining of intercellular adhesion molecule-1 (ICAM-1), E-selectin in tissue microarray slides of gastric cancer. (A) Expression of ICAM-1 was noted in the endothelial cells of gastric cancer tissues. More than 50% of cancer cells were stained (×400). (B) Expression of E-selectin was noted in the diffuse type signet ring gastric cancer cells. More than 50% were stained (×400).
Mentions: From 157 gastric cancer tissues, nearly 50% (n=79) tissues were positive for ICAM-1 and 54% (n=85) were positive for E-selectin by immunohistochemical staining (Fig. 2). There was a reverse relationship between the positivity of ICAM-1 expression and positivity of E-selectin expression (Table 1).

Bottom Line: Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion.The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Korea University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Among cell adhesion molecules, serum levels of intercellular adhesion molecule-1 and E-selectin are known to be correlated with the metastatic potential of gastric cancer. In the present study, the authors investigated the expression of intercellular adhesion molecule-1 and E-selectin in gastric cancer tissues and cultured gastric cancer cells, and examined their clinical value in gastric cancer.

Materials and methods: The protein was extracted from gastric cancer tissues and cultured gastric cancer cells (MKN-28 and Kato-III) and the expression of intercellular adhesion molecule-1 and E-selectin was examined by western blotting. The clinical significance of intercellular adhesion molecule-1 and E-selectin was explored, using immunohistochemical staining of specimens from 157 gastric cancer patients.

Results: In western blot analysis, the expressions of intercellular adhesion molecule-1 in gastric cancer tissues and cultured gastric cancer cells were increased, however, E-selectin in gastric cancer tissues and cells were not increased. Among 157 gastric cancer patients, 79 patients (50%) were intercellular adhesion molecule-1 positive and had larger tumor size, an increased depth of tumor invasion, lymph node metastasis and perineural invasion. The intercellular adhesion molecule-1 positive group showed a higher incidence of tumor recurrence (40.5%), and a poorer 3-year survival than the negative group (54.9 vs. 85.9%, respectively).

Conclusions: Intercellular adhesion molecule-1 is overexpressed in gastric cancer tissues and cultured gastric cancer cells, whereas E-selectin is not overexpressed. Increased expression of intercellular adhesion molecule-1 in gastric cancer could be related to the aggressive nature of the tumor, and has a poor prognostic effect on gastric cancer.

No MeSH data available.


Related in: MedlinePlus