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Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50.

Cohn BA, Terry MB, Plumb M, Cirillo PM - Breast Cancer Res. Treat. (2012)

Bottom Line: PCB 167 was associated with a lower risk (odds ratio (OR), 75th vs. 25th percentile = 0.2, 95 % confidence interval (95 % CI) 0.1, 0.8) as was PCB 187 (OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1).In contrast, PCB 203 was associated with a sixfold increased risk (OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7).It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.

View Article: PubMed Central - PubMed

Affiliation: Child Health and Development Studies, Public Health Institute, 1683 Shattuck Avenue, Berkeley, CA 94709, USA. bcohn@chdstudies.org

ABSTRACT
Discrete windows of susceptibility to toxicants have been identified for the breast, including in utero, puberty, pregnancy, and postpartum. We tested the hypothesis that polychlorinated biphenyls (PCBs) measured during the early postpartum predict increased risk of maternal breast cancer diagnosed before age 50. We analyzed archived early postpartum serum samples collected from 1959 to 1967, an average of 17 years before diagnosis (mean diagnosis age 43 years) for 16 PCB congeners in a nested case-control study in the Child Health and Development Studies cohort (N = 112 cases matched to controls on birth year). We used conditional logistic regression to adjust for lipids, race, year, lactation, and body mass. We observed strong breast cancer associations with three congeners. PCB 167 was associated with a lower risk (odds ratio (OR), 75th vs. 25th percentile = 0.2, 95 % confidence interval (95 % CI) 0.1, 0.8) as was PCB 187 (OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1). In contrast, PCB 203 was associated with a sixfold increased risk (OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7). The net association of PCB exposure, estimated by a post-hoc score, was nearly a threefold increase in risk (OR, 75th vs. 25th percentile = 2.8, 95 % CI 1.1, 7.1) among women with a higher proportion of PCB 203 in relation to the sum of PCBs 167 and 187. Postpartum PCB exposure likely also represents pregnancy exposure, and may predict increased risk for early breast cancer depending on the mixture that represents internal dose. It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.

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Related in: MedlinePlus

Cumulative distribution of case–control differences for the PCB score (N = 112 age-matched case control pairs). Each point represents one case–control pair. The points on the right side of the y-axis (center axis) are positive values that represent pairs where the woman who developed breast cancer had a higher PCB score postpartum than her matched control. In a majority of pairs (62 %), the woman who subsequently developed breast cancer had a higher PCB score. The differential for the PCB score was also greater for pairs where the case had a higher score than her matched control (compare points on the right of the y-axis to points on the left of the y-axis)
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Fig1: Cumulative distribution of case–control differences for the PCB score (N = 112 age-matched case control pairs). Each point represents one case–control pair. The points on the right side of the y-axis (center axis) are positive values that represent pairs where the woman who developed breast cancer had a higher PCB score postpartum than her matched control. In a majority of pairs (62 %), the woman who subsequently developed breast cancer had a higher PCB score. The differential for the PCB score was also greater for pairs where the case had a higher score than her matched control (compare points on the right of the y-axis to points on the left of the y-axis)

Mentions: Figure 1 shows the actual distribution of the within-pair differences for the PCB score for cases versus controls in this study sample. In the majority of case–control pairs (62 %), the PCB score was higher among the woman who subsequently developed breast cancer. Pairs where the case had a higher PCB score also showed greater differences on the PCB score than pairs where the control had a higher score (seen in Fig. 1; compare the right side of the Y-axis (center axis) which shows pairs where cases within the pair had a higher PCB score to the left side of the Y-axis which shows pairs where controls had a higher PCB score). Figure 1 is consistent with the modeling results shown in Tables 2, 3 and 4.Fig. 1


Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50.

Cohn BA, Terry MB, Plumb M, Cirillo PM - Breast Cancer Res. Treat. (2012)

Cumulative distribution of case–control differences for the PCB score (N = 112 age-matched case control pairs). Each point represents one case–control pair. The points on the right side of the y-axis (center axis) are positive values that represent pairs where the woman who developed breast cancer had a higher PCB score postpartum than her matched control. In a majority of pairs (62 %), the woman who subsequently developed breast cancer had a higher PCB score. The differential for the PCB score was also greater for pairs where the case had a higher score than her matched control (compare points on the right of the y-axis to points on the left of the y-axis)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3473187&req=5

Fig1: Cumulative distribution of case–control differences for the PCB score (N = 112 age-matched case control pairs). Each point represents one case–control pair. The points on the right side of the y-axis (center axis) are positive values that represent pairs where the woman who developed breast cancer had a higher PCB score postpartum than her matched control. In a majority of pairs (62 %), the woman who subsequently developed breast cancer had a higher PCB score. The differential for the PCB score was also greater for pairs where the case had a higher score than her matched control (compare points on the right of the y-axis to points on the left of the y-axis)
Mentions: Figure 1 shows the actual distribution of the within-pair differences for the PCB score for cases versus controls in this study sample. In the majority of case–control pairs (62 %), the PCB score was higher among the woman who subsequently developed breast cancer. Pairs where the case had a higher PCB score also showed greater differences on the PCB score than pairs where the control had a higher score (seen in Fig. 1; compare the right side of the Y-axis (center axis) which shows pairs where cases within the pair had a higher PCB score to the left side of the Y-axis which shows pairs where controls had a higher PCB score). Figure 1 is consistent with the modeling results shown in Tables 2, 3 and 4.Fig. 1

Bottom Line: PCB 167 was associated with a lower risk (odds ratio (OR), 75th vs. 25th percentile = 0.2, 95 % confidence interval (95 % CI) 0.1, 0.8) as was PCB 187 (OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1).In contrast, PCB 203 was associated with a sixfold increased risk (OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7).It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.

View Article: PubMed Central - PubMed

Affiliation: Child Health and Development Studies, Public Health Institute, 1683 Shattuck Avenue, Berkeley, CA 94709, USA. bcohn@chdstudies.org

ABSTRACT
Discrete windows of susceptibility to toxicants have been identified for the breast, including in utero, puberty, pregnancy, and postpartum. We tested the hypothesis that polychlorinated biphenyls (PCBs) measured during the early postpartum predict increased risk of maternal breast cancer diagnosed before age 50. We analyzed archived early postpartum serum samples collected from 1959 to 1967, an average of 17 years before diagnosis (mean diagnosis age 43 years) for 16 PCB congeners in a nested case-control study in the Child Health and Development Studies cohort (N = 112 cases matched to controls on birth year). We used conditional logistic regression to adjust for lipids, race, year, lactation, and body mass. We observed strong breast cancer associations with three congeners. PCB 167 was associated with a lower risk (odds ratio (OR), 75th vs. 25th percentile = 0.2, 95 % confidence interval (95 % CI) 0.1, 0.8) as was PCB 187 (OR, 75th vs. 25th percentile = 0.4, 95 % CI 0.1, 1.1). In contrast, PCB 203 was associated with a sixfold increased risk (OR, 75th vs. 25th percentile = 6.3, 95 % CI 1.9, 21.7). The net association of PCB exposure, estimated by a post-hoc score, was nearly a threefold increase in risk (OR, 75th vs. 25th percentile = 2.8, 95 % CI 1.1, 7.1) among women with a higher proportion of PCB 203 in relation to the sum of PCBs 167 and 187. Postpartum PCB exposure likely also represents pregnancy exposure, and may predict increased risk for early breast cancer depending on the mixture that represents internal dose. It remains unclear whether individual differences in exposure, response to exposure, or both explain risk patterns observed.

Show MeSH
Related in: MedlinePlus