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Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.

Dwivedi OP, Tabassum R, Chauhan G, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D - PLoS ONE (2012)

Bottom Line: We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups.The effect sizes of rs9939609 on BMI and WC were ~2 fold higher in children than adults.The other variant rs8050136 was in strong linkage disequilibrium with rs9939609 (r(2) = 0.97) and provided similar association results.

View Article: PubMed Central - PubMed

Affiliation: Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.

ABSTRACT

Background: FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course. Although studies have shown association of FTO variants with adiposity in adult Indian, its association in Indian children is yet to be confirmed.

Methods: Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children. We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups.

Results: The variant rs9939609 showed significant association with risk of obesity [OR = 1.21, P = 2.5 × 10(-3)] and its measures BMI, weight, waist circumference and hip circumference [β range = 0.11 to 0.14 Z-score units; P range = 1.3 × 10(-4) to 1.6 × 10(-7)] in children. The observed effect sizes in Indian children were similar to those reported for European children. Variant rs9939609 explained 0.88% of BMI variance in Indian children. The effect sizes of rs9939609 on BMI and WC were ~2 fold higher in children than adults. Interestingly rs9939609 was also associated with serum levels of thyroid stimulating hormone (TSH) [β = 0.10 Z-score, P = 5.8 × 10(-3)]. The other variant rs8050136 was in strong linkage disequilibrium with rs9939609 (r(2) = 0.97) and provided similar association results.

Conclusion: The study provides first report of association of FTO variants with obesity and related anthropometric traits in Indian children with higher impact in children compared to adults. We also demonstrated association of FTO variant with serum levels of TSH, indicating putative influence of FTO in hypothalamic-pituitary-thyroid axis.

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Related in: MedlinePlus

Variance in adiposity measures explained by FTO variant rs9939609 in Indian children and adults.BMI: body mass index; WC: waist circumference; HC: hip circumference; WHR: waist-to-hip ratio. Data for children were taken from present study while the data for adults were taken from a recent meta-analysis (up to 17,124 subjects) on South Asian adults by Li etal[13].
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pone-0047772-g001: Variance in adiposity measures explained by FTO variant rs9939609 in Indian children and adults.BMI: body mass index; WC: waist circumference; HC: hip circumference; WHR: waist-to-hip ratio. Data for children were taken from present study while the data for adults were taken from a recent meta-analysis (up to 17,124 subjects) on South Asian adults by Li etal[13].

Mentions: The rs9939609 showed significant association with risk of obesity in children [OR = 1.21, P = 2.5×10−3 for additive model] (Table 2). Consistently, we also observed significant association of the risk allele (Table 2) with increase in BMI [β = 0.14 Z-score unit, P = 1.6×10−7], weight [β = 0.12, P = 1.1×10−5], WC [β = 0.12, P = 1.7×10−5] and HC [β = 0.11, P = 1.3×10−4]. We also performed association analysis assuming dominant and recessive genetic models. Association result for variant rs9939609 under dominant model [OR = 1.23, P = 1.2×10−2] was similar to additive model [OR = 1.21, P = 2.5×10−3]. However, we observed slightly higher effect size under recessive model [OR = 1.46, P = 1.8×10−3] compared to additive and dominant models. Variant rs9939609 explains 0.65% to 0.88% of the inter-individual variation in measures of obesity (Figure 1). Further, we explored gender differences in the effect of FTO variants on obesity measures. We did not find any significant difference in the effect of FTO variants among boys and girls for any anthropometrical traits (Table S2).


Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.

Dwivedi OP, Tabassum R, Chauhan G, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D - PLoS ONE (2012)

Variance in adiposity measures explained by FTO variant rs9939609 in Indian children and adults.BMI: body mass index; WC: waist circumference; HC: hip circumference; WHR: waist-to-hip ratio. Data for children were taken from present study while the data for adults were taken from a recent meta-analysis (up to 17,124 subjects) on South Asian adults by Li etal[13].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3472993&req=5

pone-0047772-g001: Variance in adiposity measures explained by FTO variant rs9939609 in Indian children and adults.BMI: body mass index; WC: waist circumference; HC: hip circumference; WHR: waist-to-hip ratio. Data for children were taken from present study while the data for adults were taken from a recent meta-analysis (up to 17,124 subjects) on South Asian adults by Li etal[13].
Mentions: The rs9939609 showed significant association with risk of obesity in children [OR = 1.21, P = 2.5×10−3 for additive model] (Table 2). Consistently, we also observed significant association of the risk allele (Table 2) with increase in BMI [β = 0.14 Z-score unit, P = 1.6×10−7], weight [β = 0.12, P = 1.1×10−5], WC [β = 0.12, P = 1.7×10−5] and HC [β = 0.11, P = 1.3×10−4]. We also performed association analysis assuming dominant and recessive genetic models. Association result for variant rs9939609 under dominant model [OR = 1.23, P = 1.2×10−2] was similar to additive model [OR = 1.21, P = 2.5×10−3]. However, we observed slightly higher effect size under recessive model [OR = 1.46, P = 1.8×10−3] compared to additive and dominant models. Variant rs9939609 explains 0.65% to 0.88% of the inter-individual variation in measures of obesity (Figure 1). Further, we explored gender differences in the effect of FTO variants on obesity measures. We did not find any significant difference in the effect of FTO variants among boys and girls for any anthropometrical traits (Table S2).

Bottom Line: We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups.The effect sizes of rs9939609 on BMI and WC were ~2 fold higher in children than adults.The other variant rs8050136 was in strong linkage disequilibrium with rs9939609 (r(2) = 0.97) and provided similar association results.

View Article: PubMed Central - PubMed

Affiliation: Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.

ABSTRACT

Background: FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course. Although studies have shown association of FTO variants with adiposity in adult Indian, its association in Indian children is yet to be confirmed.

Methods: Here we examined association of FTO variants (rs9939609 and rs8050136) with obesity and related anthropometric and biochemical traits in 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children. We also compared effects observed in the present study with that observed in previous studies on South Asian adults and children of other ethnic groups.

Results: The variant rs9939609 showed significant association with risk of obesity [OR = 1.21, P = 2.5 × 10(-3)] and its measures BMI, weight, waist circumference and hip circumference [β range = 0.11 to 0.14 Z-score units; P range = 1.3 × 10(-4) to 1.6 × 10(-7)] in children. The observed effect sizes in Indian children were similar to those reported for European children. Variant rs9939609 explained 0.88% of BMI variance in Indian children. The effect sizes of rs9939609 on BMI and WC were ~2 fold higher in children than adults. Interestingly rs9939609 was also associated with serum levels of thyroid stimulating hormone (TSH) [β = 0.10 Z-score, P = 5.8 × 10(-3)]. The other variant rs8050136 was in strong linkage disequilibrium with rs9939609 (r(2) = 0.97) and provided similar association results.

Conclusion: The study provides first report of association of FTO variants with obesity and related anthropometric traits in Indian children with higher impact in children compared to adults. We also demonstrated association of FTO variant with serum levels of TSH, indicating putative influence of FTO in hypothalamic-pituitary-thyroid axis.

Show MeSH
Related in: MedlinePlus